N-(tri(hydroxymethyl)methyl)glycine

Vapour pressure

Administrative data

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

15 Jan 2018 - 18 Mar 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Test guideline 3

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7950 (Vapor Pressure)

GLP compliance:

no

Type of method:

effusion method: isothermal thermogravimetry

Test material

Test material information

Constituent 1

Reference substance name:

N-(tri(hydroxymethyl)methyl)glycine

EC Number:

227-193-6

EC Name:

N-(tri(hydroxymethyl)methyl)glycine

Cas Number:

5704-04-1

Molecular formula:

C6H13NO5

IUPAC Name:

2-{[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino}acetic acid

Test material form:

solid: particulate/powder

Results and discussion

Vapour pressure

Vapour pressure 1

Key result

Temp.:

ca. 20 °C

Vapour pressure:

< 0.002 Pa

Vapour pressure 2

Key result

Temp.:

ca. 25 °C

Vapour pressure:

< 0.004 Pa

Any other information on results incl. tables

In the range of 100°C and 150°C no significant weight lost was observed. A log pversus1/T curve for the test item in the range of 110°C - 130°C could not be determined since the coefficient of correlation (r) was < 0.99 (data is archived in the raw data). From 160°C weight lost was observed. The weight loss was due to reaction and/or decomposition of the test item from 160°C.

Since no accurate vapour pressure could be calculated from the obtained results the weight losses of the test item were compared with the results of hexachlorobenzene at the same temperatures. The weight loss curve of this reference substance is shown inFigure 4. Since the weight loss of the test item was lower than the weight loss of the reference compound, the vapour pressure of the test item is considered to be below the vapour pressure of hexachlorobenzene.

             
Results of the Vapour pressure Isothermal TGA Analysis

Temperature	Weight loss	νT	log νT	log PT	PT
[°C]	[µg/min]	[g/cm^2/h]			[Pa]
110	0.025469	3.04 ´ 10^-6	-5.52	-1.93	1.2 x 10^-2
110	0.015069	1.80 ´ 10^-6	-5.75	-2.22	6.1 x 10^-3
120	0.001492	1.78 ´ 10^-7	-6.75	-3.5	3.1 x 10^-4
120	0.024896	2.97 ´ 10^-6	-5.53	-1.94	1.2 x 10^-2
130	0.02485	2.97 ´ 10^-6	-5.53	-1.94	1.2 x 10^-2
130	0.064001	7.64 ´ 10^-6	-5.12	-1.41	3.9 x 10^-2

Applicant's summary and conclusion

Conclusions:

The isothermal TGA effusion method was applied for the determination of the vapour pressure of the test substance. The vapour pressure was determined to be < 1.5 x 10-3 Pa at 20 degree C and < 4.0 x 10-3 at 25 degree C.

Executive summary:

The isothermal TGA effusion method was applied for the determination of the vapour pressure of the test substance. The vapour pressure was determined to be < 1.5 x 10-3 Pa at 20 degree C and < 4.0 x 10-3 at 25 degree C.