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EC number: 200-317-6 | CAS number: 57-15-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14-Sep-2017 to 09-Mar-20 18
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 E (Ready biodegradability: Modified OECD Screening Test)
- Version / remarks:
- Two treatments with sodium benzoate were used instead of one treatment as stated in
chapter 9.3 of the study plan. On the other hand, in chapter 1 0.3.1.2 of the study plan two
treatments with Na-Benzoate are given. This discrepancy in the study plan may be
regarded a deviation of the study plan which is not considered to have an influence on the
integrity of the study.
• Temperature values were temporarily outside the range 22 ± 2°C being set. The reason for
this is due to failure of the air conditioning on day 22. Thus, this deviation has no influence
on the results and the integrity of the test.
• ln deviation to the study plan, the sampling date planned on l21d was done on hod and the
sampling date planned on t27d was omitted. - Deviations:
- yes
- Remarks:
- see remarks
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 1,1,1-trichloro-2-methyl-2-propanol hemihydrate
- Cas Number:
- 6001-64-5
- Molecular formula:
- C4H7Cl3O H2O
- IUPAC Name:
- 1,1,1-trichloro-2-methyl-2-propanol hemihydrate
- Test material form:
- solid: crystalline
- Details on test material:
- transparent and crystalline solid at ambient temperature
Constituent 1
Study design
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Details on inoculum:
- The effluent from the municipal sewage treatment plant at Taunusstein-Bleidenstadt was filtered through cotton filter. The first approximately 200 ml of filtrate were discarded. The inoculum obtained was used on the same day of preparation.
- Duration of test (contact time):
- 28 d
Reference substanceopen allclose all
- Reference substance:
- benzoic acid, sodium salt
- Remarks:
- control ltem
- Reference substance:
- other: Potassium hydrogenphthalate
- Remarks:
- reference item for the DOC analyses
Results and discussion
% Degradationopen allclose all
- Parameter:
- % degradation (DOC removal)
- Remarks:
- first experiment
- Value:
- 88
- Sampling time:
- 28 d
- Remarks on result:
- other:
- Remarks:
- for detailed information see table 1
- Key result
- Parameter:
- % degradation (DOC removal)
- Value:
- 99
- Sampling time:
- 28 d
- Remarks on result:
- other:
- Remarks:
- for detailed information see table 2
Any other information on results incl. tables
table 1: results first experiment
time (d) | DOC (mg/l) | Degradation |
0 | 33.33 | - |
1 | 31.17 | 6 |
7 | 22.17 | 34 |
9 | 20.62 | 38 |
14 | 19.28 | 42 |
20 | 15.57 | 53 |
28 | 3.99 | 88 |
table 2: results second experiment
time (d) | DOC (mg/l) | Degradation |
0 | 31.62 | - |
1 | 29.18 | 8 |
7 | 13.68 | 57 |
9 | 11.16 | 65 |
14 | 4.42 | 86 |
20 | 4.19 | 87 |
28 | 0.49 | 99 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- Study is valid an the test substance is readily biodegradable.
- Executive summary:
Chlorobutanol Hemihydrate was tested for biodegradability according to OECD 301 E. Calculated from the DOC content of the test item at time to and the measured DOC at different times, 88% of the DOC has been removed from the 1st test solution with the test item within 28d of test period. 99% of the DOC has been removed from the secend treatment with the test item within 28d. The calculated mean degradation value of the test item was 93% and thus beyond the threshold for "ready biodegradability of 70% DOC-removal. By graphical analysis, the "10-days-window" was met only in the secend treatment with the test item. The first treatment did not fulfil this criterion. Thus, the test item may be regarded as "not readily biodegradable" though a mean degradation value of 93% was achieved within 28 days. The control item sodium benzoate was degraded 100% within 20 days of incubation. The conditions of the "10 -days-window" were met within 7 days (95% degradation) in the secend treatment. According to graphical analysis, the conditions of the 10-days-window were also met in the 1st treatment though there was a slight delay in that treatment. 99% degradation was obtained in that 1st treatment with Na-benzoate after 14 days. Thus the test is regarded to be valid. The results obtained with the toxicity control indicate that there was no toxicity of the test item towards microorganisms at the concentration used within the test as a degradation value of >30% (here: 97%) was achieved in total within that treatment. The 10-days-window was also met in that treatment. This indicates that the test item is rapidly co-metabolized together with sodium benzoate, and thus, the failure of the "10-days-window" in the first treatment with the test item alone should be neglected.
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