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EC number: 269-595-4 | CAS number: 68299-15-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
one Guideline study on acute toxicity by the oral route available
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July - August 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material:
16JSVA015
- Expiration date of the lot/batch:
14. September 2018
- Purity test date:
not state
RADIOLABELLING INFORMATION (if applicable)
not applicable
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material:
Room Temperature: (20 ± 5°C), keep container tightly closed, store under inert gas
- Stability under test conditions:
assumed stable
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
none - Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dobrá Voda, Slovak Republic
- Females (if applicable) nulliparous and non-pregnant: yes
- Age at study initiation: 8-12 weeks
- Weight at study initiation: 190 - 200 g
- Fasting period before study: over night
- Housing: in gorups of 3
- Diet (e.g. ad libitum): The laboratory food ssniff (Spezialdiäten GmbH, Germany) was
offered at recommended doses each day approximately at the same
time.
- Water (e.g. ad libitum): Supply of
drinking was unlimited.
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22.7 ± 0.7° C,
- Humidity (%): 55.1 ± 3.1 %.
- Air changes (per hr): central air conditioning, no value given
- Photoperiod (hrs dark / hrs light): 12-hour light /12-hour dark
IN-LIFE DATES: From: To: - Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: not stated
- Amount of vehicle (if gavage): not stated
- Justification for choice of vehicle: Olive oil is a standard vehicle according to OECD TG 423
- Lot/batch no. (if required): L61067
- Purity: not applicable
MAXIMUM DOSE VOLUME APPLIED: 2000 mg/kg bw
DOSAGE PREPARATION (if unusual): not applicable
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose:
Available information indicated that the test item is likely to be non-toxic; therefore, a limit dose of 2000 mg/kg body weight was used as a starting dose. - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days ´
- Frequency of observations:
Animals were observed individually immediately after administration of the test item and 0.5, 1, 2, and 4 hours later. Each animal was inspected daily for the next 14 days.
Observations included: changes in skin, fur, eyes, mucous membranes, respiratory, circulatory, autonomic and central nervous systems, somatomotor activity, and behavioural pattern. Particular attention was given to potential neurologic endpoints such as tremors, convulsions, salivation, diarrhoea, lethargy, sleep and coma
and weighing:
Individual weights of animals were measured immediately prior to test item was administered and
weekly thereafter. Weight differences after first and second weeks after administration were
calculated and recorded
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, - Statistics:
- none applied
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Five of six females survived the limit dose of 2000 mg/kg body weight.
Female No 6 was
lethargic from Day 5 to Day 12 and died on Day 13 post-treatment. - Clinical signs:
- other: Lethargy and sleepiness between 0.5 and 4 hours after treatment was observed in all animals. These observations in animals No 1, 2 and 3 were noticed on Day 1 post-treatment too. Female No 6 was lethargic from Day 5 to Day 12 and died on Day 13 post-treat
- Gross pathology:
- All animals were necropsied. During necropsy, no macroscopic findings were observed in females
No 1-5. Adrenomegaly, petechial haemorrhages on the gastric mucosa in female No 6 were registered. - Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 of the test item Bis(neodecanoyloxy)dioctylstannane is greater than 2000 mg/kg body
weight after single oral administration to Wistar rats. - Executive summary:
The purpose of the study was to evaluate the potential toxic effect of the test item
Bis(neodecanoyloxy)dioctylstannane when administered as a single oral dose to Wistar rats. The
procedure according to OECD Guideline 423 Acute Toxic Class (ATC) method was used.
Available information indicated that the test item is likely to be non-toxic; therefore, a limit dose of
2000 mg/kg body weight was used as a starting dose.
One group of 3 females was dosed. Due to lethargy of all animals, next step proceeded after 7 days.
Test item-related mortality was not observed during 7 days; another 3 females were treated with the
same dose.
Five females survived the limit dose. One female died on Day13 post-treatment. Lethargy and
sleepiness between 0.5 and 4 hours after treatment was observed in all animals. These observations
in animals No 1, 2 and 3 were noticed on Day 1 post-treatment too. From Day 5 to Day 12 female No
6 was lethargic and this animal died on Day 13 post-treatment.
During post-treatment time, the rest animals displayed neither signs of intoxication, change of health,
nor any other adverse reaction. Stagnation of the body weight in 4 animals, slight increase of the body
weight in 1 animal and decrease of the body weight in 1 animal between the first and second week
were observed.
During necropsy, no macroscopic findings were observed in 5 females. In died female adrenomegaly,
petechial haemorrhages on the gastric mucosa were registered.
The LD50 of the test item Bis(neodecanoyloxy)dioctylstannane is greater than 2000 mg/kg body
weight after single oral administration to Wistar rats.
Based on Annex 2d Test Procedure with a Starting Dose of 2000 mg/kg body weight of OECD
Guideline 423 it can be concluded that the test item Bis(neodecanoyloxy)dioctylstannane is classified
in GHS Category 5 (> 2000 – 5000) with a LD50 cut off value equal to 2500 mg/kg body weight, after
single oral administration to Wistar rats.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 25 March 2013 to 11 April 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results. The study report was conclusive, done to a valid guideline and the study was conducted under GLP conditions.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- yes
- Remarks:
- (On one occasion the relative humidity was recorded below the protocol range with a recording of 44 %. This study deviation neither affected the overall interpretation of study findings nor compromised the integrity of the study.)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- yes
- Remarks:
- (On one occasion the relative humidity was recorded below the protocol range with a recording of 44 %. This study deviation neither affected the overall interpretation of study findings nor compromised the integrity of the study.)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
- Species:
- rat
- Strain:
- other: HsdHan™:WIST
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan UK Limited, Bicester, UK
- Age at study initiation: 8 - 9 weeks
- Weight at study initiation: 179 - 196 g
- Fasting period before study: animals were fasted from the evening of the day prior to dosing (Day -1) until approximately 3 hours after dosing
- Housing: animals were housed in groups of up to five during the acclimatisation period in cages that conform to the 'Code of Practice for the Housing and Care of Animals Used in Scientific Procedures' (Home Office, London, 1989). From the day prior to dosing (Day –1), the rats were housed in groups of three in similar cages.
- Diet: SQC(E) Rat and Mouse Maintenance Diet No 1, from Special Diets Services Ltd, Witham, UK, ad libitum
- Water: mains water, ad libitum
- Acclimation period: 7 - 9 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24 °C
- Humidity (%): 45 - 65 %
- Air changes (per hr): 15 - 20 air changes per hour
- Photoperiod (hrs dark / hrs light): 12 hours dark / 12 hours light
In order to enrich both the environment and the welfare of the animals, they were provided with wooden Aspen chew blocks, nesting materials and rodent retreats. Environmental enrichment materials were removed during the period of fasting from the evening of the day prior to dosing (Day -1) until approximately 3 hours after dosing. - Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- - Individual doses
Individual doses (mL) were calculated using the fasted body weights of the rats on the morning of dosing (Day 1) and the specific gravity for the neat material.
- Dose volume
The test material was used as supplied. The specific gravity was determined and used to calculate the appropriate dose volume for the required dose level.
During the study, the animals were treated with a dose volume of 1.87 mL/kg - Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 3 animals initially then a further 3 animals once the survival of the previously treated animals was confirmed.
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: All animals were examined at the beginning and end of the working day throughout the acclimatisation and study periods to ensure they were in good health. Treated rats were observed closely for clinical signs of reaction to treatment. Clinical signs were recorded immediately post dose, at approximately 15 and 30 minutes post dose, hourly between 1 and 4 hours post dose (inclusive), twice daily on Days 2, 3 and 4 and once daily from the fifth to last day of the observation period.
- Frequency of weighing: Individual body weights were recorded on Day 1 (day before dosing) and on Days 1, 4, 8 and 15.
- Necropsy of survivors performed: yes. A full macroscopic necropsy was performed and all lesions were recorded. The necropsy procedure included inspection of external surfaces and orifices, all viscera and tissue within the abdominal, thoracic and cranial cavities, free hand sectioning of the liver and kidneys and examination of representative sections of mucosal surfaces of the stomach, small and large intestines. No tissue preservation or histopathological assessment of tissues was undertaken.
- Other examinations performed: yes (gene analysis)
Blood samples for gene analysis (0.5 mL nominal) were taken from all animals on Day -1 and Day 1 (24 hours after dosing).
Samples were taken from jugular vein into into trisodium citrate anticoagulant. Samples were mixed gently by hand then continuously for at least 2 minutes on automatic mixer. Once mixed the 3 samples from each group, at each timepoint, were pooled together and placed in a cooled Kryorack. The resultant plasma was separated, transferred to uniquely labelled clear polypropylene tubes and frozen immediately at <–50 °C. - Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None of the animals died during the study.
- Clinical signs:
- other: No clinical signs were seen during the study.
- Gross pathology:
- No abnormalities were noted at necropsy.
- Other findings:
- Gene analysis findings were not reported.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of the study, the acute median dose level of the test material was found to exceed 2000 mg/kg.
- Executive summary:
The acute oral toxicity of the test material was investigated in a GLP study which was conducted in accordance with the standardised guidelines OECD 423 and EU Method B.1 tris, following the Acute Toxic Class method.
During the study two groups of 3 female rats were sequentially treated with test material at dose level of 2000 mg/kg bw. The test material was administered orally, by gavage, without dilution. All animals were killed on Day 15 and subsequently underwent a full necropsy.
There were no deaths and no signs of toxicity. All rats achieved body weight gains during the first and second weeks of the study. No abnormalities were noted at necropsy. Therefore, under the conditions of the study, the acute median dose level of the test material was found to exceed 2000 mg/kg.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- not reported
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The data are taken from an abstract of a journal with nlimited information regarding the methodology; it is not possible to assess the accuracy of the information.
- Principles of method if other than guideline:
- Limited information is mentioned in the literature regarding methods.
- GLP compliance:
- not specified
- Test type:
- other: unknown
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- - Fasting before administration.
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- - Single dose.
- Details on study design:
- - Observed for 21 days.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 6 450 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test material was reported to have an LD50 of 6450 mg/kg which is above the limits of classification.
- Executive summary:
The oral toxicity of the test material was determined to be LD₅₀ 6450 mg/kg. Male rats were exposed to a single dose of the test material and observed for 21 days. There is limited information available as the study is written in German. The LD₅₀ is above the limit of classification and so the substance is "not classified" according to Regulation 1272/2008.
- Endpoint:
- acute toxicity: oral
- Type of information:
- other: Handbook data
- Adequacy of study:
- supporting study
- Study period:
- not reported
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The data are taken from an abstract of an handbook with no reported methodology; it is not possible to assess the accuracy of the information.
- Principles of method if other than guideline:
- The value is taken from a secondary source citing Schering, which is unpublished. Test guidelines or methods are not mentioned in the literature.
- GLP compliance:
- not specified
- Test type:
- other: Not reported
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 4 000 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 of the test material was reported to be > 4000 mg/kg, which is above the limit of classification.
- Executive summary:
The oral toxicity of the test material is reported from an unpublished secondary source. The LD₅₀ in rats is recorded as > 4000 mg/kg. No information is available regarding the method used, so it is not possible to assess the accuracy of the data. The reported LD₅₀ is above the limit of classification and so the substance is "not classified" according to Regulation 1272/2008.
- Endpoint:
- acute toxicity: oral
- Type of information:
- other: Handbook data
- Adequacy of study:
- supporting study
- Study period:
- Not reported
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The data are taken from an abstract of a handbook with no reported methodology; it is not possible to assess the accuracy of the information.
- Principles of method if other than guideline:
- The value is taken from a secondary source citing Barth et al (1964). Test guidelines or methods are not mentioned in the literature.
- GLP compliance:
- not specified
- Test type:
- other: not reported
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 6 000 - 6 450 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test material was reported to have an LD50 of between 6000-6450 mg/kg which is above the limits of classification.
- Executive summary:
The acute oral toxicity of the test material in rats was recorded as LD₅₀ 6000-6450 mg/kg. The data have been reported as a secondary source and information regarding the methodology is not available. It is not possible to assess the accuracy of the data. The reported LD₅₀ is above the limit of classification and so the substance is "not classified" according to Regulation 1272/2008.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- not reported
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The data is taken from an abstract of an internet source with no reported methodology; it is not possible to assess the accuracy of the information.
- Principles of method if other than guideline:
- Test guidelines or methods are not mentioned in the literature.
- GLP compliance:
- not specified
- Test type:
- other: not reported
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 6 450 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test material was reported to have an LD50 of 6450 mg/kg which is above the limits of classification.
- Executive summary:
The test material is recorded to have an LD₅₀ of 6450 mg/kg, a cited in the literature. There is no information available regarding the method used or what is actually the original source, so it is not possible to assess the accuracy of the data. The recorded LD₅₀ is above the limit of classification and so the substance is "not classified" according to Regulation 1272/2008.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- tudy conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results. The study report was conclusive, done to a valid guideline and the study was conducted under GLP conditions.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- additional blood sampling for determination of absorption
- Principles of method if other than guideline:
- Blood samples for toxicokinetics (0.5 mL nominal) were taken from all animals on Day 1 at 3 and 24 hours after dosing.
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
- Species:
- rat
- Sex:
- male/female
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg / kg bw
- No. of animals per sex per dose:
- 5 male and female
- Control animals:
- not required
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 2 000 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- The acute median lethal dermal dose of TIB KAT 216 to rats was found to exceed 2000 mg/kg.
Reference
Clinical signs following treatment
Dose level: 2000 mg/kg
Clinical sign |
Animal number and sex |
||||
29M |
30M |
31M |
32M |
33M |
|
No observations |
ü |
ü |
ü |
ü |
ü |
Clinical sign |
Animal number and sex |
||||
34F |
35F |
36F |
37F |
38F |
|
No observations |
ü |
ü |
ü |
ü |
ü |
Dermal reactions
Dose level: 2000 mg/kg
Day |
Dermal reaction |
Animal number and sex |
||||
29M |
30M |
31M |
32M |
33M |
||
2 to 15 |
Erythema Oedema |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
Day |
Dermal reaction |
Animal number and sex |
||||
34F |
35F |
36F |
37F |
38F |
||
2 to 15 |
Erythema Oedema |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
Individual body weights and weekly increments
Dose level (mg/kg) |
Animal number and sex |
Body weight (g) at: |
Increment (g) |
|||||
Day -1 |
Day 1 |
Day 4 |
Day 8 |
Day 15 |
Day 1 to 8 |
Day 8 to 15 |
||
2000 |
29M |
257 |
266 |
273 |
279 |
308 |
13 |
29 |
30M |
260 |
269 |
269 |
279 |
294 |
10 |
15 |
|
31M |
279 |
286 |
284 |
289 |
307 |
3 |
18 |
|
32M |
268 |
271 |
272 |
281 |
294 |
10 |
13 |
|
33M |
269 |
281 |
283 |
293 |
306 |
12 |
13 |
|
2000 |
34F |
181 |
188 |
195 |
189 |
203 |
1 |
14 |
35F |
201 |
207 |
203 |
213 |
216 |
6 |
3 |
|
36F |
180 |
183 |
179 |
190 |
202 |
7 |
12 |
|
37F |
178 |
186 |
178 |
191 |
200 |
5 |
9 |
|
38F |
195 |
202 |
202 |
210 |
222 |
8 |
12 |
Necropsy findings
Dose level:2000 mg/kg
Animal number and sex |
Time and manner of death (Day) |
Necropsy comments |
29M |
15T |
No macroscopic changes
|
30M |
15T |
No macroscopic changes
|
31M |
15T |
No macroscopic changes
|
32M |
15T |
No macroscopic changes
|
33M |
15T |
No macroscopic changes
|
34F |
15T |
No macroscopic changes
|
35F |
15T |
No macroscopic changes
|
36F |
15T |
Liver: raised area, right median lobe - 9 mm diameter raised area protruding into thoracic cavity - moderate # |
37F |
15T |
No macroscopic changes
|
38F |
15T |
No macroscopic changes
|
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 001 ng/kg bw
Additional information
Justification for classification or non-classification
The available information is conclusive but not sufficient for classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.