Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 223-786-9 | CAS number: 4073-98-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- november 15th 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Justification for type of information:
- The study was conducted according to a EU guideline study. No deviation affected the quality of the study. The substance is considered to be adequately characterised. Therefore full validation applies.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)
- Version / remarks:
- 1981
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7520 (Particle Size, Fiber Length, and Diameter Distribution)
- Version / remarks:
- 1996
- Qualifier:
- according to guideline
- Guideline:
- ISO 13320 (Particle size analysis - Laser diffraction methods)
- Version / remarks:
- 2009
- Principles of method if other than guideline:
- The particle size distribution is determined using laser diffraction. As measuring device, a Malvern Mastersizer 2000 is used. The powder is brought via a powder dispersing cell Scirocco 2000 into the laser light beam and the diffraction pattern is determined. From the diffraction pattern the particle size distribution is calculated.
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- (inspected on 11 & 12 October 2016 / signed on 28 Feb. 2017)
- Type of method:
- Laser scattering/diffraction
- Type of particle tested:
- other: powder
- Type of distribution:
- volumetric distribution
- Percentile:
- D10
- Mean:
- 5.7 µm
- St. dev.:
- 0.1
- Percentile:
- D50
- Mean:
- 97.7 µm
- St. dev.:
- 3.7
- Percentile:
- D90
- Mean:
- 541.2 µm
- St. dev.:
- 34.1
- No.:
- #1
- Size:
- < 500 µm
- Distribution:
- 88.5 %
- No.:
- #2
- Size:
- < 100 µm
- Distribution:
- 50.5 %
- No.:
- #3
- Size:
- < 10 µm
- Distribution:
- 18 %
- No.:
- #4
- Size:
- < 4 µm
- Distribution:
- 6.5 %
- Conclusions:
- The test substance contains a limited fraction of particles fine enough to be inhaled and reach the thoracic fraction.
Dust explosion potential should be considered. - Executive summary:
The granulometry of the test substance was determined under GLP according to ISO13320 and OECD 110 guidelines, with laser diffraction method, in air.
The distribution was a non-symetric Gaussian curve, with a median diameter of 97.7 µm.
With regard to inhalation potential, about 50.5% of total particles are smaller than 100 µm, ca 18.0% could reach the thoracic fraction (<10 µm) and ca 6.5% are lower than 4µm.
Fine particles relevant to dust explosion hazard (<500 µm) account for 88.5%.
Reference
Result
Light Microscopy
The optically investigation of the test item with different magnifications is shown in Figure1 in the experimental report. For a better visualization a 10x10 grid with 100 µm squares was used. At all three magnifications agglomerates can be observed.
Particle Size Distribution
Two test series of 3 measurements each were performed with the test item.From each 3-fold measurement anaverage value wascalculated.The final result was calculated as mean value from the average values of the two samples.
Test series 1 |
D10 |
D50 |
D90 |
Test 1 |
5.7 |
101.9 |
579.3 |
Test 2 |
5.6 |
96.8 |
511.7 |
Test 3 |
5.5 |
94.7 |
537.2 |
Averaged |
5.6 |
97.8 |
542.0 |
Test series 2 |
D10 |
D50 |
D90 |
Test 1 |
5.7 |
96.8 |
535.8 |
Test 2 |
5.8 |
101.5 |
541.6 |
Test 3 |
5.6 |
94.5 |
544.3 |
Averaged |
5.7 |
97.6 |
540.4 |
Test series 1:
D10: 5.6 µm
D50: 97.8 µm (Median diameter)
D90: 542.0 µm
Test series 2 :
D10: 5.7 µm
D50: 97.6 µm (Median diameter)
D90: 540.4 µm
Average
D10: 5.7 µm
D50: 97.7 µm (Median diameter
D90: 541.2 µm
The results in Volume % passing at 4, 10, 100 and 500 µm:
Particle size (µm) |
Volume under (%) / Average 1 |
Volume under (%) / Average 2 |
Volume under (%) / Mean |
4 |
6.5 |
6.4 |
6.5 |
10 |
18.0 |
17.9 |
18.0 |
100 |
50.4 |
50.5 |
50.5 |
500 |
88.5 |
88.5 |
88.5 |
Description of key information
Median diameter (D50) = 97.7 µm
Respirable fraction (<4µm) = 6.5%
Thoracic fraction (<10 µm) = 18.0%
Inhalable fraction (<100 µm) = 50.5%
Dust particles (<500 µm) = 88.5 % (dust explosion potential)
Additional information
A reliable experimental study, conducted according to a recognized OECD/ISO guideline, and under GLP, is available. Despite minor restrictions due to measurement of a single batch, it is considered as a key study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.