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Diss Factsheets
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EC number: 947-976-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: U.S. 16 CFR 1500.40
- Principles of method if other than guideline:
- Acute dermal toxicity test in rabbits using U.S. method dictated by 16 CFR 1500.40, similar to OECD 402.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-hydroxyethyl ricinoleate
- EC Number:
- 203-369-8
- EC Name:
- 2-hydroxyethyl ricinoleate
- Cas Number:
- 106-17-2
- Molecular formula:
- C20H38O4
- IUPAC Name:
- 2-hydroxyethyl 12-hydroxyoctadec-9-enoate
- Reference substance name:
- 2,3-dihydroxypropyl 12-hydroxy-9-octadecenoate
- EC Number:
- 205-455-0
- EC Name:
- 2,3-dihydroxypropyl 12-hydroxy-9-octadecenoate
- Cas Number:
- 141-08-2
- Molecular formula:
- C21H40O5
- IUPAC Name:
- 2,3-dihydroxypropyl 12-hydroxyoctadec-9-enoate
- Test material form:
- liquid
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Ten healthy NZ White rabbits were used, equally divided by sex, with body weights between 2.3 and 3.0 kg. Animals were housed individually and allowed Purina Rabbit Chow and water ad libitum.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped, abraded and intact skin
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 2000 mg/kg bw. Using a body weight estimate of 2.5 kg, approximatley 5 g or 5 ml of test material was applied.
- Duration of treatment / exposure:
- 24 h
- Observation period:
- 14 days
- Number of animals:
- 10 total, 5 males and 5 females
- Details on study design:
- The hair of the animals was clipped, and in 4/10 animals, the skin was abraded with epidermal incisions every 2-3 cm longitudinally over the application area. In the remaining animals, application of test material was made to intact skin. Each animal received a single dermal application of 2000 mg/kg bw. The test material was held in contact with the skin for 24 h by a heavy gauge plastic, covered with an opaque wrapping. After 24 h, the wrappings were removed and the skin gently wiped to remove any remaining test material. Animals were then observed for mortality and signs of irritation and toxicity frequently during the first day, and at least once daily thereafter for 14 days. Necropsy examinations were performed for gross organ pathology. Body weights were recorded initally and for survivors, at termination of the study.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.5
- Max. score:
- 8
- Reversibility:
- fully reversible
- Irritant / corrosive response data:
- Erythema and edema was noted in all animals by the end of 24 h, and continued through 48 h as reflected in interim clinical notations. By 72 h, recovery had occurred and all animals were noted as "normal" on day 4. At the end of the study, all test sites were noted as "normal".
- Other effects:
- Diarrhea was noted in 4 of 10 animals. No lethality was observed in this study.
Applicant's summary and conclusion
- Interpretation of results:
- other: non-irritating
- Conclusions:
- Irritation information on the test substance was obtained in an acute dermal toxicity study in rabbits, after a 24 hour occlusive exposure. Some skin irritation was seen between 24 and 72 h, which was fully reversible by day 4. Under the conditions of the current OECD guideline, the substance is expected to be non-irritating.
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