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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 18 May - 20 May 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- For the read-across justification see section 13.
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes
- Remarks:
- according to the Japanese GLP Standard
- Specific details on test material used for the study:
- PHYSICO-CHEMICAL PROPERTIES
- Melting point: 48 °C
- Boiling point: 225 °C
- Vapour pressure: 1 mmHg (at 121 °C)
- Water solubility: 4.81 mg/L (at 25 °C)
- log Pow: 4.2 - Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: control, nominal concentration: 0.95, 1.71, 3.09, 5.56, 10.0 and 18.0 mg/L
- Sampling method: test solution was directly sampled from each vessel at study initiation and after 24 hours exposure. Water was changed after 24 hours.
- Sample storage conditions before analysis: analysis was conducted immediately after sampling, no storage - Vehicle:
- yes
- Details on test solutions:
- - Method: test substance was diluted in dilution water with dispersant
- Controls: dilution water with/without vehicle
- Chemical name of vehicle (dispersant): HCO-50
- Concentration of vehicle in test medium (final test solution(s) including control(s)): 100 mg/L
- Evidence of undissolved material (e.g. precipitate, surface film, etc): no precipitate was observed - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Source: breed in-house (origin: Incorporated Administrative Agency, National Institute for Environmental Studies, Tsukuba, Japan)
- Age at study initiation (mean and range, SD): max 24 hours
- Feeding during test: no
ACCLIMATION
- Acclimation period for parental animals: 16 days
- Acclimation conditions (same as test or not): similar to test condition (animals per unit volume: acclimation condition: 20 - 50 animals/L, test condition: 5 animals/100 mL)
- Type and amount of food: Chlorella vulgaris, 0.1 - 0.2 mgC (organic carbon content)/day
- Health during acclimation (any mortality observed): mortality was low and no presence of males and ephippia - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- hardness of the diluted water was 25.3mg/L(CaCO3 conversion)
- Test temperature:
- 20+/-1ºC
- pH:
- 6.7-7.2
- Dissolved oxygen:
- 7.6 - 8.9 mg/L (> 60 % of saturated oxygen in all testing containers)
- Nominal and measured concentrations:
- nominal concentration: 0.95, 1.71, 3.09, 5.56, 10.0 and 18.0 mg/L
measured concentration (geometric mean): <0.8, 1.5, 2.6, 5.6, 10.8 and 19.9 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: 100 mL beaker
- Material, fill volume: glass, 100 mL
- Renewal rate of test solution (frequency): once in 24 hours
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- No. of vessels per vehicle control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: dilution water was M4 medium
OTHER TEST CONDITIONS
- Photoperiod: 16 : 8 hours day-night regime
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
immobility
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 1.8
- Range finding study: performed
- Results used to determine the conditions for the definitive study: EC50 for 48 hours: 13.4 mg/L (nominal concentration), test system: static was not suitable for this substance (the testing substance concentration was significantly decreased in all concentration classes; quantifying the test substance concentration was not possible.) - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate (reagent grade)
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 3.6 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: other: 2.6 - 5.6 mg/L
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 1.5 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- Mortality of control: not observed
- Results with reference substance (positive control):
- - Results with reference substance valid? Yes
- EC50 for 48 hours: 0.60 mg/L - Reported statistics and error estimates:
- Binominal test and probit test
- Validity criteria fulfilled:
- yes
- Conclusions:
- Lauric acid shows toxic effects to aquatic invertebrates at 3.6 mg/L.
Thus Reaction mass of stearic acid and stearic anhydride does not has to be classified.
Reference
Table 1: Measured concentration of lauric acid
Nominal Concentration (mg/L) |
Measured Concentration (mg/L) |
Percent of Nominal |
|||
0 Hour new |
24 Hour Old |
Geometric Mean |
0 Hour new |
24 Hour old |
|
Control |
< 0.8 |
< 0.8 |
- |
- |
- |
Dispersant Control |
< 0.8 |
< 0.8 |
- |
- |
- |
0.95 |
0.8 |
< 0.8 |
< 0.8 |
84.2 |
- |
1.71 |
2.0 |
1.1 |
1.5 |
117 |
64.3 |
3.09 |
3.3 |
2.0 |
2.6 |
107 |
64.7 |
5.56 |
6.3 |
4.9 |
5.6 |
113 |
88.1 |
10.0 |
11.6 |
10.1 |
10.8 |
116 |
101 |
18.0 |
21.0 |
18.8 |
19.9 |
117 |
104 |
new: freshly prepared test solution
old: test solutions after 24 hours exposure period
Table 2: Immobility of Daphnia magna
Measured Concentration (mg/L) |
Cumulative Number of Dead or Immobilized Daphnia (Percent Mortality or Immobility) |
|
|
24 Hour |
48 Hour |
Control |
0 (0) |
0 (0) |
Dispersant Control |
0 (0) |
0 (0) |
< 0.8 |
0 (0) |
0 (0) |
1.5 |
0 (0) |
0 (0) |
2.6 |
1 (5) |
1 (5) |
5.6 |
15 (75) |
20 (100) |
10.8 |
15 (75) |
20 (100) |
19.9 |
13 (65) |
20 (100) |
Description of key information
Lauric acid shows toxic effects to aquatic invertebrates at 3.6 mg/L.
Thus Reaction mass of stearic acid and stearic anhydride does not has to be classified.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- 3.6 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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