Glycine, N-methyl-, N-coco acyl derivs., sodium salts

Toxicity to aquatic algae and cyanobacteria

Link to relevant study record(s)

Reference

Endpoint:

toxicity to aquatic algae and cyanobacteria

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Remarks:

Summary of available data used for the endpoint assessment of the target substance.

Adequacy of study:

key study

Justification for type of information:

Refer to the analogue approach justification provided in IUCLID section 13.

Reason / purpose for cross-reference:

read-across source

Duration:

72 h

Dose descriptor:

EC10

Effect conc.:

4.448 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth rate

Remarks on result:

other:

Remarks:

source, RA-A, CAS 30364-51-3, Chemex, ENV11320/ECO161127, 2017, P. subcapitata, 72 h, RL1

Duration:

72 h

Dose descriptor:

EC50

Effect conc.:

13.47 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth rate

Remarks on result:

other:

Remarks:

Key, source, RA-A, CAS 30364-51-3, Chemex, ENV11320/ECO161127, 2017, P. subcapitata, 72 h, RL1

Duration:

72 h

Dose descriptor:

NOEC

Effect conc.:

3.2 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth rate

Remarks on result:

other:

Remarks:

Key, source, RA-A, CAS 30364-51-3, Chemex, ENV11320/ECO161127, 2017, P. subcapitata, 72 h, RL1

Conclusions:

After 72 h inhibition of growth was observed in the two highest test concentrations (10 and 32 mg/L) resulting in an ErC50 (72 h) of 13.47 mg/L (nominal) and an ErC10 (72 h) of 4.448 mg/L (nominal).

Description of key information

ErC50 (72 h) = 13.47 mg/L (nominal, OECD 201, P. subcapitata); read-across

ErC10 (72 h) = 4.448 mg/L (nominal, OECD 201, P. subcapitata); read-across

Key value for chemical safety assessment

EC50 for freshwater algae:

13.47 mg/L

EC10 or NOEC for freshwater algae:

4.448 mg/L

Additional information

No studies investigating the toxicity to algae are available for Glycine, N-methyl-, N-coco acyl derivatives, sodium salts (CAS 61791-59-1). Therefore, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substance Sodium N-methyl-N-(1-oxotetradecyl)aminoacetate (CAS 30364-51-3) was conducted. Based on the high degree of similarity between the structural and physico-chemical properties of the target and source substance, the source substance is considered suitable representatives for the evaluation of the toxicity to algae of the target substance. The read-across approach is justified in detail within the analogue justification in IUCLID section 13.

The GLP-study with the source substance Sodium N-methyl-N-(1-oxotetradecyl)aminoacetate (CAS 30364-51-3) was conducted according to the OECD guideline 201. The first main test did not meet the validity criteria as the coefficient of variation of the replicates for the control was > 7% for the 72-hour test period. Therefore, this main test was repeated. All validity criteria for the second main test were met. The freshwater algae Pseudokirchneriella subcapitata was exposed for 72 h to nominal test concentrations of 0.32, 1.0, 3.2, 10.0, and 32.0 mg/L. No analytical measurement was conducted. After 72 h inhibition of growth was observed in the two highest test concentrations (10 and 32 mg/L) resulting in an ErC50 (72 h) of 13.47 mg/L (nominal) and an ErC10 (72 h) of 4.448 mg/L (nominal).

Based on the available results from one structurally related read-across substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a comparable structure, it can be concluded that Glycine, N-methyl-, N-coco acyl derivatives (CAS 68411-97-2) will exhibit comparable effects on aquatic algae.

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