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EC number: 273-574-5 | CAS number: 68990-02-3
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Principles of method if other than guideline:
- To determine the water solubility of the test substance employing the flask method. The flask method was chosen in line with the properties of the test substance (multi-component solid).
- GLP compliance:
- yes
- Type of method:
- flask method
- Specific details on test material used for the study:
- Test item: Na salts of hydrogenated rosin (FORAL NC®)
Batch number: CKS4107
Chemical name: Resin acids and rosin acids, hydrogenated, sodium salts
CAS no.: 68990-02-3
EC no.: 273-574-5
Purity (certified): 100% (the certificate of analysis is given in part 10)
Appearance: Pale yellow solid
Expiry date : 2019-09-01
Recommended storage: 2 to 8 °C, under nitrogen and protected from light - Key result
- Water solubility:
- 7.56 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- > 48 - < 72 h
- Temp.:
- 20 °C
- pH:
- 7.5
- Remarks on result:
- other: Loading phase not available
- Details on results:
- The water solubility of the test item was determined at 20 °C +/- 0.5 °C and pH 7.5 to be 4.86 mg/L for the first compound group, 2.25 mg/L for the second compound group and 0.451 mg/L for the third compound group, resulting in a sum of 7.56 mg/L. The water solubility was determined for the samples with pre incubation times of 48 and 72 h.
- Conclusions:
- The water solubility of Na salts of hydrogenated rosin was determined at 20 ± 0.5 °C and pH 7.5 to be 4.86 mg/L for the first compound group, 2.25 mg/L for the second compound group and 0.451 mg/L for the third compound group, resulting in a sum of 7.56 mg/L. The water solubility was determined for the samples with pre incubation times of 48 and 72 h.
- Executive summary:
The water solubility of Na salts of hydrogenated rosin (FORAL NC®)(batch:CKS4107) was determined according to OECD guideline 105 (1995) and Council Regulation (EC) No. 260/2014, Method A.6.
The solubility of the test itemNa salts of hydrogenated rosin (FORAL NC®) was determined using the flask method at 20 ± 0.5 °C with pre‑incubation at 30 ± 0.5 °C.
The test item was quantified based on the sum of three test item groups. A compound group consists of multiple signals at one m/z ratio, the content of each group was determined by additional analysis of standard samples.
The analytical method (LC‑MS, external standard) for the determination of the test itemNa salts of hydrogenated rosin (FORAL NC®) was validated and tested with satisfactory results in regard to linearity, accuracy, precision and specificity for each of the 3 test item compound groups.
The water solubility was determined for the samples with pre‑incubation times of 48 and 72 h. The water solubility of the test item was determined at 20 ± 0.5 °C and pH 7.5 to be 4.86 mg/L for the first compound group, 2.25 mg/L for the second compound group and 0.451 mg/L for the third compound group, resulting in a sum of 7.56 mg/L.
Reference
Description of key information
The water solubility of Na salts of hydrogenated rosin (FORAL NC®)(batch:CKS4107) was determined according to OECD guideline 105 (1995) and Council Regulation (EC) No. 260/2014, Method A.6.
The solubility of the test itemNa salts of hydrogenated rosin (FORAL NC®) was determined using the flask method at 20 ± 0.5 °C with pre‑incubation at 30 ± 0.5 °C.
The test item was quantified based on the sum of three test item groups. A compound group consists of multiple signals at one m/z ratio, the content of each group was determined by additional analysis of standard samples.
The analytical method (LC‑MS, external standard) for the determination of the test itemNa salts of hydrogenated rosin (FORAL NC®)was validated and tested with satisfactory results in regard to linearity, accuracy, precision and specificity for each of the 3 test item compound groups.
The water solubility of the test item was determined at 20 ± 0.5 °C and pH 7.5 to be 4.86 mg/L for the first compound group, 2.25 mg/L for the second compound group and 0.451 mg/L for the third compound group, resulting in a sum of 7.56 mg/L. The water solubility was determined for the samples with pre‑incubation times of 48 and 72 h.
Key value for chemical safety assessment
- Water solubility:
- 7.56 mg/L
- at the temperature of:
- 20 °C
Additional information
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