Registration Dossier
Registration Dossier
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EC number: 213-361-6 | CAS number: 939-48-0
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The key values are based on two key studies, each conducted in accordance with an established guideline and GLP. An estimated LC50 based on nominal concentrations was determined from a laboratory range-finding study on the toxicity of the substance to the marine fish, turbot. An LC50 based on measured concentrations was determined in a second study on the toxicity of methyl benzoate (a member of the same chemical category, based on read-across) to zebrafish, a freshwater species.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 23 mg/L
Marine water fish
Marine water fish
- Effect concentration:
- 28 mg/L
Additional information
The key value for marine fish was based on the toxicity of the substance as determined in a range-finding test on the marine turbot (Scopthalmus maximus); an estimated 96-h LC50 of 28 mg/L was reported based on nominal concentrations. The key value for freshwater fish was based on the toxicity of methyl benzoate (a member of the same chemical category, based upon read-across) to the freshwater zebrafish (Brachydanio rerio); a 96-h LC50 of 23 mg/L was reported based on measured concentrations.
This information is from the substance, methyl benzoate, (CAS RN 93-58-3) as part of a category approach used for the assessment of several endpoints of isopropyl benzoate (CAS RN 939-48-0), the registered substance. The hypothesis for the category of Alkyl Benzoates is a common functional group (a benzoic acid ester) of similar carbon chain length. This small difference in carbon chain length and molecular weight between the ester groups of methyl benzoate and isopropyl benzoate is not anticipated to have a significant effect on toxicity or environmental behaviour. For each endpoint study based upon read-across, the category approach is substantiated by an evaluation provided in the Chemical Category Report Format (CCRF) attached to the endpoint study summary file. The CCRF provides the rationale so that the read-across information cited to fulfil the information requirements of the REACH Annexes VII-X may form the basis for classification and labelling decisions, hazard assessment and risk assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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