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EC number: 280-479-2 | CAS number: 83547-95-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: US EPA) "Primary eye irritation study", Federal Register, Vol. 43, No. 163, August 22, 1978.
- Deviations:
- not specified
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-ethylhexyl 10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-7-oxo-8-oxa-3,5-dithia-4-phosphatetradecanoate 4-oxide
- EC Number:
- 280-479-2
- EC Name:
- 2-ethylhexyl 10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-7-oxo-8-oxa-3,5-dithia-4-phosphatetradecanoate 4-oxide
- Cas Number:
- 83547-95-9
- Molecular formula:
- C30H57O7PS3
- IUPAC Name:
- 2-ethylhexyl 2-{[bis({2-[(2-ethylhexyl)oxy]-2-oxoethyl}sulfanyl)phosphoryl]sulfanyl}acetate
- Test material form:
- liquid
- Details on test material:
- - Other: Trade name D 16-051
Constituent 1
- Specific details on test material used for the study:
- TEST MATERIAL (as stated in study report): TK 12 184
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Sponsor / Batch No. 312-187
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: in house
- Weight at study initiation: 2 - 3 kg
- Housing: individually in metal cages
- Diet (e.g. ad libitum): Standard rabbit food - NAFAG, No. 814, Gossau SG, ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: minimum of 4 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 2 deg C
- Humidity (%): 55 +/- 10 %
- Photoperiod (hrs dark / hrs light): 12 / 12
IN-LIFE DATES: From: To:
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: right eye
- Amount / concentration applied:
- 0.1 mL
- Observation period (in vivo):
- 14 d
- Number of animals or in vitro replicates:
- 6 animals - unwashed
3 animals - washed - Details on study design:
- The test material was inserted into the conjunctival sac of the left eye of the rabbits and the lids were gently closed for a few seconds. The right eye was not treated and served as an untreated control. In 3 of the 9 rabbits approximately 30 seconds after treatment the treated eye was flushed with 10 ml of physiological saline. The eye irritation was appraised with a slit-lamp on day 1, 2, 3, 4, 7, 10 and 14 and was scored for each individual rabbit (Draize scoring system).
Results and discussion
In vivo
Results
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 6
- Max. score:
- 20
- Reversibility:
- fully reversible within: 14 days
- Irritant / corrosive response data:
- Unrinsed eyes:
Besides a slight irritation of the cornea (Grade 1) in one animal after 24 hours no irritation of cornea or iris was observed. Conjunctival irritation returned to normal within 14 days. The maximum mean score of 6.0 was observed after 24 hours. Grade 2 conjunctival irritation occurred in a single unwashed eye and a single washed eye at 24 hours only.
Rinsed eyes;
No irritation of cornea or iris was seen. Conjunctival irritation returned to normal within 14 days. The maximum mean score of 3.3 was observed after 24 hours. - Other effects:
- A slight sedation was observed in some animals for 7 days, thereafter only one animal was slightly sedated until day 13.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- not an eye irritant by GHS criteria
- Conclusions:
- Under these standard test conditions, TK 12 184 was mildly irritating to the rabbit eye, producing a maximum mean irritation score of 6.0 in unrinsed rabbit eyes and 3.3 in rinsed eyes. All eyes returned to normal within 14 days.
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