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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
specific investigations: other studies
Remarks:
pulmonary absoption
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Cross-reference
Reason / purpose for cross-reference:
read-across: supporting information

Data source

Reference
Reference Type:
review article or handbook
Title:
2-METHYLPENTANE (ISOHEXANE)
Author:
Galvin, Jennifer B.; Bond, Gary
Year:
1999
Bibliographic source:
Journal of Toxicology and Environmental Health, Part A, 58:1-2, pp. 81-92, DOI: 10.1080/009841099157449; http://dx.doi.org/10.1080/009841099157449

Materials and methods

Endpoint addressed:
other: pulmonary absorption

Test material

1
Chemical structure
Reference substance name:
2-methylpentane
EC Number:
203-523-4
EC Name:
2-methylpentane
Cas Number:
107-83-5
Molecular formula:
C6H14
IUPAC Name:
2-methylpentane
Test material form:
liquid

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
male

Administration / exposure

Route of administration:
inhalation
Duration of treatment / exposure:
80-100 min.
Details on study design:
1000–5000 ppm
Studies on pulmonary absorption of 20 inhaled gasoline-related hydrocarbon vapors — % of inhaled hydrocarbon retained; 80–100 min

Results and discussion

Details on results:
24.7% Uptake for 2-methyl-pentane

Applicant's summary and conclusion

Conclusions:
24.7% uptake of 2-methyl-pentane by pulmonary absoption
Executive summary:

This is a brief summary of: American Petroleum Institute. 1987. API Med. Res. Pub. 34-33036, October.