Phenylphosphonic acid

Particle size distribution (Granulometry)

Administrative data

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

02 Oct 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2017

Report date:

2017

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

ISO 13320 (Particle size analysis - Laser diffraction methods)

Test guideline 2

Qualifier:

according to guideline

Guideline:

other: CIPAC MT 187

Principles of method if other than guideline:

he analysis was conducted initially using a visual microscope and was then undertaken more formally using a Laser Diffraction Particle Size Analyser. The sample was observed under 3 conditions: Direct observation, under a microscope with 32 x magnification, under a microscope with 400 x magnification. The physical characteristics of the material were recorded, noting such items as shape and size distribution. Following this the Malvern Mastersizer 2000 Laser Diffraction Analyser was used. Five runs of the method were conducted to ensure repeatability of results.

GLP compliance:

yes (incl. QA statement)

Type of method:

Laser scattering/diffraction

Type of particle tested:

primary particle

Type of distribution:

volumetric distribution

Test material

Test material information

Constituent 1

Reference substance name:

Phenylphosphonic acid

EC Number:

216-388-1

EC Name:

Phenylphosphonic acid

Cas Number:

1571-33-1

Molecular formula:

C6H7O3P

IUPAC Name:

phenylphosphonic acid

Test material form:

solid: particulate/powder

Details on test material:

Lot number LKF6065

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Sponsor and LKF6065
- Expiration date of the lot/batch: 09 December 2017
- Purity test date: 21 October 2016

Results and discussion

Mass median aerodynamic diameter:

276.5 µm

Geometric standard deviation:

0.006

Remarks on result:

other: 0.07 % by volume of sample was seen to be < 10.00 µm.

Particle size

Particle size 1

Percentile:

D10

Mean:

< 102.755 µm

St. dev.:

1.235

Remarks on result:

other: % STDVP 1.2

Particle size 2

Percentile:

D50

Mean:

< 226.517 µm

St. dev.:

2.565

Remarks on result:

other: % STDVP 1.1

Particle size 3

Percentile:

D90

Mean:

< 429.002 µm

St. dev.:

7.646

Remarks on result:

other: % STDVP 1.8

Any other information on results incl. tables

Standard visual observation:

Sample observed to be a fine and medium size, white crystalline powder.

Observation at 32 x magnification:

The particles appeared to be irregular shaped crystals. The smallest individual particle size was approximately 19 µm and the largest individual size was approximately 576 µm.

Observation at 400 x magnification:

The sample was observed to be made up of single crystalline particles.

Applicant's summary and conclusion

Conclusions:

The mass median aerodynamic diameter was determined to be 276.5 um.