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EC number: 270-821-9 | CAS number: 68478-46-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Boron, (benzenemethanamine)trifluoro-,(t-4)-, reaction products with bu glycidyl ether was found to be corrosive in study using BTP-3-3-055-81, Biological Corrosivity, (The Code of Federal Regulations, Title 49, Chapter 1, Section 173.1200, Appendix A) test method with rabbits.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- other: BTP-3-3-055-81, Biological Corrosivity, (The Code of Federal Regulations, Title 49, Chapter 1, Section 173.1200, Appendix A).
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- The animals used were New Zealand albino rabbits, which were supplied
by Mission Laboratory Supply Company, Rosem ead, California.
They were approximately 2 1/2 to 3 1/2 months old (2 - 3 kg) at the
time of testing. A balanced Purina rabbit chow diet and water was fed
ad Libitum during the acclimation and testing periods. All test subjects
were quarantined and checked for signs of disease prior to testing.
All test animals were housed in stainless steel suspended cages.
The photoperiod was twelve (12) hours light and twelve (12) hours
darkness, and the ambient temperature was 70 - 72 degrees F.
The room in which the animals were housed received a minimum of
ten (10) complete air exchanges every hour. - Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 ml of pure material
- Duration of treatment / exposure:
- 4 h exposure period
- Observation period:
- 4 h and 48 h
- Number of animals:
- 6
- Details on study design:
- Testing was performed according to the above reference and is briefly summarized as follows :
Six (6) healthy young New Zealand rabbits were clipped free of hair dorsally and laterally on the trunk. The sample (0.5 ml ) was
then applied directly to the exposed skin of each animal and was covered with gauze squares which were securely taped and wrapped.
At the end of a four-hour exposure period, the bandages were removed and the sample was washed from the skin. Dermal reactions, erythema
eschar formation, edema, and necrosis were evaluated at 4 and 48 hours after exposure. - Irritation parameter:
- other: Irreversible Tissue Alteration
- Basis:
- mean
- Time point:
- other: 4
- Score:
- 0.5
- Max. score:
- 1
- Reversibility:
- other: 3 animals showed irreversible ulceration/necrosis of the tissue. 3 animals showed reversible changes.
- Remarks on result:
- other: 0=no permanent damage, 1=ulceration or necrosis
- Irritation parameter:
- other: Irreversible Tissue Alteration
- Basis:
- mean
- Time point:
- other: 48 h
- Score:
- 0.5
- Max. score:
- 1
- Reversibility:
- other: 3 animals showed irreversible ulceration/necrosis of the tissue. 3 animals showed reversible changes.
- Remarks on result:
- other: 0=no permanent damage, 1=ulceration or necrosis
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 4 h
- Score:
- 2.5
- Max. score:
- 4
- Reversibility:
- other: See Irreversible Tissue Alteration section
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 48 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- other: See Irreversible Tissue Alteration section
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 4 h
- Score:
- 0.5
- Max. score:
- 4
- Reversibility:
- other: see section Irreversible Tissue Alteration
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 48 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: see section Irreversible Tissue Alteration
- Irritant / corrosive response data:
- Necrosis was observed in three animals and edema was present in two of these at the 4-hour reading. Of the other three animals, one had slight
erythema and one had well-defined erythema at the 4-hour reading. - Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Boron, (benzenemethanamine)trifluoro-,(t-4)-, reaction products with bu glycidyl ether was found to be corrosive in study using BTP-3-3-055-81, Biological Corrosivity, (The Code of Federal Regulations, Title 49, Chapter 1, Section 173.1200, Appendix A) test method with rabbits.
- Executive summary:
Corrosivity of Boron, (benzenemethanamine)trifluoro-,(t-4)-, reaction products with bu glycidyl ether was tested for corrosivity using BTP-3-3-055-81, Biological Corrosivity, (The Code of Federal Regulations, Title 49, Chapter 1, Section 173.1200, Appendix A) test method with rabbits. Medium to high erythema was observed and low to medium edema was observed after 4 h exposure. After 48 h was observed permanent tissue alteration in half of the test animals.
Reference
6 animals were used in the study, exposure time 4 h.
Medium to high erythema was observed and low to medium edema was observed after 4 h exposure.
Treated area of 3 test animals recovered from the effect, for remaining 3 animals was observed permament damage of the tissue.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study need not be conducted because the available information indicates that the criteria are met for classification as corrosive to the skin or irritating to eyes
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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