Registration Dossier
Registration Dossier
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EC number: 274-092-8 | CAS number: 69709-01-9
Endpoint summary
Administrative data
Description of key information
Additional information
Reliable short-term test data are available for effects of the registration substance on Daphnia and algae.
The key values are:
Daphnia
A 48 hour EC50 value of >122 mg/l (geometric mean) (highest concentration tested) has been determined for the effects of the hydrolysis product of the test item 1,1,3,3 -tetramethyl-2-[3-(trimethoxysilyl)propyl]guanidine, on mobility of Daphnia magna, in accordance with OECD guideline 202. No effects were observed after 48 hours.
Since the pH of the test item concentration 100 mg/L was considered to be outside the recommended range of pH 6 – 9, the concentration level 100 mg/L was tested pH-adjusted (pH 8.2 ± 0.5) and un-adjusted to distinguish toxic effects of the test item from pH effects.
Algae
A 72 hour EC50 value of >131 mg/l and NOEC value of >=131 mg/l (geometric mean) (highest concentration tested) have been determined for the effects of the hydrolysis product of the test item 1,1,3,3 -tetramethyl-2-[3-(trimethoxysilyl)propyl]guanidine, on growth rate of Pseudokirchneriella subcapitata, in accordance with OECD guideline 201. No inhibition of growth was found after 72 hours.
pH adjusted test solutions were included in the study since test item can hydrolyse rapidly at higher pH values. However, as the substance is such a strong base (guanidine) it was not possible to adjust the pH enough to prevent rapid hydrolysis. The concentration level 100 mg/L was tested pH-adjusted (pH 8.2 ± 0.5) and un-adjusted to also distinguish toxic effects of the test item from pH effects.
The test organisms will have been exposed to the hydrolysis products.
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