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EC number: 262-634-6 | CAS number: 61167-58-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20 Sep - 04 Oct 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- other: “Biodegradation test of chemical substance by microorganisms” (Kanpogyo No. 5, Yakuhatsu No. 615 and 49 Kikyoku No. 392)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))
- Deviations:
- yes
- Remarks:
- Test duration only 14 d.
- GLP compliance:
- no
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): The activated sludge was purchased every three months from Chemicals Inspection & Testing Institute, Japan and cultivated in the laboratory.
- Concentration of suspended solids: 4628 ppm - Duration of test (contact time):
- 14 d
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Parameter followed for biodegradation estimation:
- test mat. analysis
- Details on study design:
- TEST SYSTEM
- Number of culture flasks/concentration: 2
- Measuring equipment: Automatically measuring apparatus of oxygen consumption (Coulometer, Ohkura Electric Co., Ltd.)
SAMPLING
- Sampling frequency: O2 consumption was measured after 7 and 14 d
- Sampling method: Measured automatically
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes, one bottle
- Toxicity control: no, but see cross-reference
- Other: reference substance: yes, one bottle - Reference substance:
- aniline
- Parameter:
- % degradation (O2 consumption)
- Value:
- 0
- Sampling time:
- 14 d
- Remarks on result:
- other: Reported as: -0.6%
- Parameter:
- % degradation (test mat. analysis)
- Value:
- 0
- Sampling time:
- 14 d
- Remarks on result:
- other: Reported as: -0.5%
- Details on results:
- The study was not performed for 28 d since it was already visible after 14 d that the substance will not be degraded by microorganisms.
- Results with reference substance:
- The reference substance was degraded to 62.3% after 7 d and 69.1% after 14 d.
- Interpretation of results:
- under test conditions no biodegradation observed
Reference
Table 1: Results of the oxygen consumption analysis
Test solutions |
Amount of sample (mg) |
Theoretical oxygen demand (mg) |
7 days |
14 days |
||
Oxygen consumption (mg) |
Degradation rate (%)* |
Oxygen consumption (mg) |
Degradation rate (%) |
|||
1) Aniline + activated sludge |
30.0 |
90.3 |
59.9 |
62.3 |
67.2 |
69.1 |
2) Activated sludge |
0 |
− |
3.6 |
− |
4.8 |
− |
3) Test item + activated sludge |
30.0 |
80.4 |
3.6 |
0 |
4.8 |
0 |
4) Test item + activated sludge |
30.3 |
81.2 |
3.0 |
-0.7 |
3.9 |
-1.1 |
5) Test item + water |
30.2 |
− |
0.3 |
− |
0.6 |
− |
6) Test item + water |
30.0 |
− |
0 |
− |
0.3 |
− |
|
Average degradation rate: -0.4 (r = 0.7) |
Average degradation rate: -0.6 (r = 1.1) |
Table 2: Biodegradation test: Results of the residual analysis by GC
Test solutions |
Amount of the test substance added A (mg) |
Amount injected (mL) |
Sensitivity (10-2A.U.) |
Peak area (Indicated value of integrator) |
Concentration of the test substance B (mg/mL) |
Total volume C (mL) |
Recovery rate D (%) |
Residual amount (mg) E = |
Residual rate (%) F=´100 |
Degra-dation rate G (%) |
Average degra- dation rate (%) |
Test item - Standard solution |
− |
4.0 |
16 |
376105 |
600 |
− |
− |
− |
− |
− |
− |
2) Activated sludge |
0 |
4.0 |
16 |
0 |
0 |
50 |
− |
− |
− |
− |
− |
3) Test item + activated sludge |
30.0 |
4.0 |
16 |
375271 |
599 |
50 |
97.2 |
30.8 |
102.7 |
-2.3 |
-0.5 (r = 3.7) |
4) Test item + activated sludge |
30.3 |
4.0 |
16 |
365709 |
583 |
50 |
97.2 |
30.0 |
99.0 |
1.4 |
|
5) Test item + water |
30.2 |
4.0 |
16 |
371786 |
593 |
50 |
96.5 |
30.7 |
101.7 |
100.4 |
− |
6) Test item + water |
30.0 |
4.0 |
16 |
359400 |
573 |
50 |
96.5 |
29.7 |
99.0 |
Description of key information
Not expected to be readily biodegradable: 0% after 14 d (O2 consumption/test material analysis, similar to OECD 301C)
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
- Type of water:
- freshwater
Additional information
One experimental study is available investigating the biodegradation of 2-(1,1-dimethylethyl)-6-[[3-(1,1-dimethylethyl)-2-hydroxy-5-methylphenyl]methyl]-4-methylphenyl acrylate (CAS 61167-58-6). The study was performed according “Biodegradation test of chemical substance by microorganisms” (Kanpogyo No. 5, Yakuhatsu No. 615 and 49 Kikyoku No. 392), which is equivalent or similar to the OECD Guideline 301C. In contrast to today’s standard methods the test duration was only 14 d. Activated sludge was exposed to 100 mg/L of the test item and the O2 consumption as well as specific test material analysis were used to assess biodegradation over time. After 14 d a biodegradation of 0% based on O2 consumption and test material analysis was recorded. Even though the test duration was only 14 d this result indicates strong evidence that the substance is not readily biodegradable according to the OECD criteria. Inhibition of activated sludge microorganisms is not likely since the available study according to OECD 209 did indicate low inhibition of the respiration of activated sludge microorganisms up to a concentration of 1000 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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