Registration Dossier
Registration Dossier
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EC number: 220-668-9 | CAS number: 2855-27-8
Endpoint summary
Administrative data
Description of key information
Additional information
Studies with 1,2,4 -Trivinylcyclohexane are available for the trophic levels fish, daphnia, algae and aquatic microorganisms. In an GLP conform guideline test on acute toxicity on daphnia, no effect was observed in a saturated solution. Therefore, the EC50 after 48 h for Daphnia magna is >15.4 mg/L. A toxicity test on Desmodesmus subspicatus with the test substance revealed an ErC50 >1.98 mg/L and an ErC10 (0-72 h) of >1.98 mg/L based on the growth rate.
In an acute toxicity test with the zebrafish according to EEC 92/69 C1 and OECD203, a LC50 of 3.2 mg/L after 96 h has been observed. However, the analytical testing has not been substance specific in this study and the concentration of saturated solution remains unclear. In a second acute study with fish, an LC50 of 652 µg/L has been determined in a semi-static test with a saturated solution obtained by a slow-stirring procedure. However, this study reveals methodological limitations as dilution levels were tested instead of preparing separated test concentration levels and two tests were conducted on different days but considered as one study. The reported effect levels (LC50) of the fish studies are above the limit of water solubility of the test substance. At the limit of the water solubility (0.35 mg/L) no effects has been reported.
A long-term reproduction study on Daphnia magna according to OECD TG 211 has been conducted in a closed system under semi-static conditions to consider the physical-chemical properties of the test substance. The NOEC (21 days) on mortality has been >=115 µg/L. The NOEC (21 d) for reproduction has been determined to be 44.4 µg/L and the EC10 (21 d) for reproduction is 41.4 µg/L. Long-term studies on fish has not been conducted, as the chemical safety assessment indicated no need to further investigations and considering animal-welfare reasons. The risk assessment of the test substance has been based on the available acute and chronic toxicity studies.
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