Registration Dossier
Registration Dossier
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EC number: 203-626-4 | CAS number: 108-89-4
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is readily biodegradable
- Justification for type of information:
- According to Regulation (EC) No.1907/2006, Annex VIII, Section 9.2.2.1, Column 2, hydrolysis testing as a function of pH does not need to be conducted if the substance is readily biodegradable. The substance has been shown to be readily biodegradable, based on read-across from 3-Methylpyridine (another substance in the chemical category). The determination of the ready biodegradability of the substance is supported by the results of the non-guideline study by Lee et al. (2005), which showed complete degradation of 0.5mM (i.e., 46.6 mg/L) 4-methylpyridine in activated sludge, by a filamentous bacterium isolated from the culture identified as Pseudonocardia sp. In addition, the results of the non-guideline study by Stoban et al. (2008) in actinomyces bacteria suggest that 4-methylpyridine is likely to be readily biodegradable.
Reference
Description of key information
According to Regulation (EC) No.1907/2006, Annex VIII, Section 9.2.2.1, Column 2, hydrolysis testing as a function of pH does not need to be conducted if the substance is readily biodegradable. The substance has been shown to be readily biodegradable, based on read-across from 3-Methylpyridine (another substance in the chemical category), and supported by information on the substance itself.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
