Registration Dossier
Registration Dossier
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EC number: 284-111-1 | CAS number: 84787-70-2 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Santalum album, Santalaceae.
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- before 1971
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Safety Assessment of sandalwood oil (Santalum album L.)
- Author:
- G.A. Burdock, I.G.Carabin
- Year:
- 2 008
- Bibliographic source:
- Food and Chemical Toxicology 46 (2008) 421-432
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- original study referenced as RIFM report by Shelanski, M.V. 1971, cited in Opdyke 1974 (Opdyke, D.L.J, 1974, Reviews of fragrance raw materials. Sandalwood oil, East Indian. Food and Cosmetics Toxicology 12 (supp.) A26)
- GLP compliance:
- no
Test material
- Reference substance name:
- 5-(2,3-dimethyltricyclo[2.2.1.02,6]hept-3-yl)-2-methylpent-2-en-1-ol, stereoisomer
- EC Number:
- 204-102-8
- EC Name:
- 5-(2,3-dimethyltricyclo[2.2.1.02,6]hept-3-yl)-2-methylpent-2-en-1-ol, stereoisomer
- Cas Number:
- 115-71-9
- Molecular formula:
- C15H24O
- IUPAC Name:
- 5-(2,3-dimethyltricyclo[2.2.1.0~2,6~]hept-3-yl)-2-methylpent-2-en-1-ol
- Reference substance name:
- [1S-[1α,2α(Z),4α]]-2-methyl-5-(2-methyl-3-methylenebicyclo[2.2.1]hept-2-yl)-2-penten-1-ol
- EC Number:
- 201-027-2
- EC Name:
- [1S-[1α,2α(Z),4α]]-2-methyl-5-(2-methyl-3-methylenebicyclo[2.2.1]hept-2-yl)-2-penten-1-ol
- Cas Number:
- 77-42-9
- Molecular formula:
- C15H24O
- IUPAC Name:
- 2-methyl-5-(2-methyl-3-methylenebicyclo[2.2.1]hept-2-yl)pent-2-en-1-ol
- Reference substance name:
- (Z)-5-[(6R)-4,6-dimethyl-6-bicyclo[3.1.1]hept-3-enyl]-2-methylpent-2-en-1-ol
- Cas Number:
- 176777-61-0
- Molecular formula:
- C15H24O
- IUPAC Name:
- (Z)-5-[(6R)-4,6-dimethyl-6-bicyclo[3.1.1]hept-3-enyl]-2-methylpent-2-en-1-ol
- Reference substance name:
- (E)-(R)-(+)-5-(2,3-dimethyltricyclo[2.2.1.0^2,6]hept-3-yl)-2-methyl-2-penten-1-ol
- Cas Number:
- 14490-17-6
- Molecular formula:
- C15H24O
- IUPAC Name:
- (E)-(R)-(+)-5-(2,3-dimethyltricyclo[2.2.1.0^2,6]hept-3-yl)-2-methyl-2-penten-1-ol
- Reference substance name:
- 2-Hepten-1-ol, 2-methyl-6-(4-methylphenyl)-, (2Z)-
- Cas Number:
- 122442-36-8
- Molecular formula:
- C15H22O
- IUPAC Name:
- 2-Hepten-1-ol, 2-methyl-6-(4-methylphenyl)-, (2Z)-
- Test material form:
- liquid
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Constituent 5
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Apparently, the study cited as "Shelanski, 1971" was mentioned in two review articles (Opdyke 1974 and Burke, 2008), reporting an acute dermal toxicity of > 5 g/kg in rabbits. Further details are not reported. The original study, reported as internal communication to RIFM, is not available.
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