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EC number: 249-385-9 | CAS number: 29043-70-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The key 28-day oral study, conducted according to OECD TG 407, and in compliance with GLP, reported a NOAEL value for dimethylbis(octadecyloxy)silane of ≥1000 mg/kg bw in rats (RCC, 1999).
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The key 28-day oral study, conducted with dimethylbis(octadecyloxy)silane according to OECD TG 407, and in compliance with GLP, reported a NOAEL value of ≥1000 mg/kg bw in rats (RCC, 1999).
In this study, doses of 50, 200, 1000 mg/kg bw/day of test material in
corn oil were administered orally to 5 male and 5 female rats for 28
days. Observations for mortality and clinical signs of toxicity were
performed daily during the study period. Detailed clinical observations
were performed once a week, as well as body weights were recorded prior
to commencement of treatment, then weekly and prior to scheduled death.
Neurobehavioral examinations including grip strength and motor activity
were performed on week 4 of the study period. Blood samples for
haematological and clinical chemistry examinations were collected from
all the animals during week 4 of the study. At the end of the study
period all animals were sacrificed and gross pathological examinations
were performed. Organs were collected and some of them were weighed and
used for samples preparation for histopathological examination. Negative
control group animals were also included. No deaths occurred during the
28 -day study period. No changes in expected body weight gain were
observed in any of the test animals. No qualitative or quantitative
differences were noted in any of the test animals when compared to the
control group. No test article-related differences were noted at
haematological and clinical chemistry examinations. No treatment-related
changes were noted in organ weights or structure at macroscopic
examinations. A number of microscopic findings were noted. The type,
incidence and severity of these findings were not considered
treatment-related.
Justification for classification or non-classification
Based on the available data for dimethylbis(octadecyloxy)silane, no classification for specific target organ toxicity following repeated exposure is required according to
Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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