Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 252-279-5 | CAS number: 34907-26-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Read across to 2,3-dinitrotoluene - see attached document for details.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Two male cats were administered either 10 or 50 mg/kg bw of 2,4-DNT (purity = 99%) by
gavage in lutrol. - GLP compliance:
- no
- Remarks:
- Data from collection/ handbook, no informaiton on completion date or compliace is available.
- Test type:
- other: Two male cats were administered either 10 or 50 mg/kg bw of 2,4-DNT (purity = 99%) by gavage in lutrol.
- Limit test:
- no
Test material
- Reference substance name:
- 2,4-dinitrotoluene
- EC Number:
- 204-450-0
- EC Name:
- 2,4-dinitrotoluene
- Cas Number:
- 121-14-2
- Molecular formula:
- C7H6N2O4
- IUPAC Name:
- 1-methyl-2,4-dinitrobenzene
- Test material form:
- solid
- Details on test material:
- Molecule for read-across studies
Constituent 1
- Specific details on test material used for the study:
- purity = 99%
Test animals
- Species:
- cat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: lutrol
- Details on oral exposure:
- Two male cats were administered either 10 or 50 mg/kg bw of 2,4-DNT (purity = 99%) by
gavage in lutrol. - Doses:
- 10 or 50 mg/kg bw of 2,4-DNT (purity = 99%)
- No. of animals per sex per dose:
- 1
- Control animals:
- no
- Details on study design:
- Two male cats were administered either 10 or 50 mg/kg bw of 2,4-DNT (purity = 99%) by
gavage in lutrol. - Statistics:
- N/A
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 50 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Toxic effects were found at the high dose. The cause of death of the high-dose cat 1 week after treatment was renal
insufficiency. - Clinical signs:
- Toxic effects were found at the high dose. Methaemoglobin levels increased
up to 42% within 7 hours after treatment, and then those decreased to basal levels after 48
hours. Nevertheless, Heinz-bodies were noted within 48 hours after treatment (55%). - Other findings:
- Methaemoglobin levels increased up to 42% within 7 hours after treatment, and then those decreased to basal levels after 48 hours. Nevertheless, Heinz-bodies were noted within 48 hours after treatment (55%).
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- Based on cat data (death following oral administration of 50 mg/kg b.w.) 2,4-DNT is considered to be classified for acute toxicity as toxic by oral exposure at Category 3.
- Executive summary:
Therefore, based on cat data (death following oral administration of 50 mg/kg b.w.) 2,4-DNT
is considered to be classified for acute toxicity as toxic by oral exposure. Since oral and
inhalation absorption values were estimated to be 100% in experimental animals and humans,
it seems reasonable to extrapolate toxicity by inhalation from oral toxicity data and to classify
2,4-DNT as toxic by inhalation. Finally, taking into account that the dermal absorption value
was estimated to be 10% in rodent and by extrapolation in experimental animals and humans,
2,4-DNT should be considered as borderline toxic by dermal exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.