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Diss Factsheets
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EC number: 204-198-1 | CAS number: 117-57-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity: LD50 ca. 1700 mg/kg bw; RL4; pre-GLP; rats showed clinical signs such as urine being yellower than normal, bad general condition, partly red crusted nose and snout, apathy as well as initial weight loss. During gross pathology, acute cardiac dilatation with congestive hyperemia, bloody gastric ulcerations and haematinized intestinal contents were observed.
Acute inhalation toxicity: mortality (rat): none; RL4, pre-GLP; no clinical signs or gross pathological evidence was observed. However, no exposure concentration was reported in the study report.
Acute dermal toxicity: discriminating dose >2500 mg/kg bw; RL4; pre-GLP; during the observation period, no death occurred and no clinical or gross pathological signs were observed.
Acute toxicity (other routes; intraperitoneal): LD50 (mouse) ca. 470 mg/kg bw; RL4; pre-GLP; clinical signs observed were slight apathy, partly dyspnoea, at high doses twitching and spring cramps. During gross pathology, intraabdominal substance precipitation was observed.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Principles of method if other than guideline:
- no information available
- GLP compliance:
- no
- Remarks:
- Study conducted prior to implementation of GLP
- Test type:
- standard acute method
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 2-30% - Doses:
- 1700 mg/kg; observation after 7 days
- Control animals:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 700 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- none
- Clinical signs:
- urine yellower than normal; bad general condition, partly red crusted nose and snout and apathy
- Body weight:
- Initial weight loss
- Gross pathology:
- acute cardiac dilatation with congestive hyperemia, bloody gastric ulcerations, haematinized intestinal contents
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The oral LD50 of 3-hydroxy-2-methylquinoline-4-carboxylic acid in rats was ca. 1700 mg/kg bw.
- Executive summary:
In an acute oral toxicity study, rats were given a single oral dose of 3-hydroxy-2-methylquinoline-4-carboxylic acid in aqueous suspension with carboxymethyl cellulose and were then observed for 7 days.
During the observation period, clinical signs were urine being yellower than normal, bad general condition, partly red crusted nose and snout, apathy as well as initial weight loss. During gross pathology, acute cardiac dilatation with congestive hyperemia, bloody gastric ulcerations and haematinized intestinal contents were observed.
Oral LD50 (rats) ca. 1700 mg/kg bw
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 700 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Principles of method if other than guideline:
- No information provided
- GLP compliance:
- no
- Remarks:
- Study conducted prior to implementation of GLP
- Test type:
- concentration x time method
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- not specified
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Temperature in air chamber: 20°C
VEHICLE
- Composition of vehicle: air (not further specified) - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- >= 3 - <= 480 min
- Concentrations:
- not specified (air passed through 5 cm layer of test substance)
- No. of animals per sex per dose:
- 12 animals (sex not specified)
- Control animals:
- not specified
- Remarks on result:
- other: No LC50 determined
- Mortality:
- none
- Clinical signs:
- other: none
- Body weight:
- not specified
- Gross pathology:
- none
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Inhalation of 3-hydroxy-2-methylquinoline-4-carboxylic acid showed no effects.
- Executive summary:
In an acute inhalation to 3-hydroxy-2-methylquinoline-4-carboxylic acid in air for up to 8 hours.
During the observation period, no death occurred and no clinical signs or gross pathological evidence was observed.
Mortality (rats): none
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- An inhalation study (concentration x time method) was conducted in rats. No information about the exposure concentration was reported. Therefore the study is not suitable for assessment and classification.
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Principles of method if other than guideline:
- no information available
- GLP compliance:
- no
- Remarks:
- Study conducted prior to implementation of GLP
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Type of coverage:
- not specified
- Vehicle:
- water
- Details on dermal exposure:
- TEST MATERIAL
- Concentration: 50% (aqueous grinding) - Control animals:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- none
- Clinical signs:
- none
- Gross pathology:
- none
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The dermal LD50 of 3-hydroxy-2-methylquinoline-4-carboxylic acid in rats was > 2500 mg/kg bw.
- Executive summary:
In an acute toxicity study, rats were given a single dose of 50% 3-hydroxy-2-methylquinoline-4-carboxylic acid (aqueous grinding) at a dose of 2500 mg/kg bw and were observed for 14 days.
During the observation period, no death occurred and no clinical or gross pathological signs were observed.
Dermal LD50 (rats) > 2500 mg/kg bw
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 500 mg/kg bw
Additional information
Acute toxicity (other routes; intraperitoneal); adverse effect observed; LD50 ca. 470 mg/kg bw
Justification for classification or non-classification
Acute oral toxicity
Based on relevant and adequate data, the test substance has to be classified and labelled according to the CLP Regulation (EC) No 1272/2008 with respect to acute oral toxicity, Category 4.
Acute inhalation toxicity
No exposure concentration was reported in the study report and no LC50 was determined. Therefore the study cannot be used for classification.
Acute dermal toxicity
Based on relevant and adequate data, the test substance does not need to be classified and labelled according to the CLP Regulation (EC) No 1272/2008 with respect to acute dermal toxicity.
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