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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

No mortality or toxicologically significanr observations were see at a single oral dose of 2000 mg/kg. The composition of test material in this early study was reported to be 65% 1,5-Naphtalene disulfonic acid, 10.8% sodium. There are no acute dermal or inhalation studies available.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
15 - 29 Mar 1989
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: GLP compliant study conducted similar to OECD guideline 401 with only minor limitations
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
not applicable
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes
Species:
rat
Strain:
Wistar
Sex:
male/female
Route of administration:
oral: gavage
Vehicle:
other: demineralised water
Doses:
2000 mg/kg bw (nominal)
No. of animals per sex per dose:
5
Control animals:
no
Sex:
male/female
Dose descriptor:
LD0
Effect level:
2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality and no signs of systemic toxicity were observed
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
discriminating dose
Value:
2 000 mg/kg bw
Quality of whole database:
Early study conducated simi9lar to OECD TG 401

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification

Classification is not warranted because no mortality or toxicologically significanr observations were reported at a single oral dose of 2000 mg/kg of the test material (containing 65% 1,5-Naphtalene disulfonic acid and 10.8% sodium).