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Diss Factsheets
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EC number: 269-084-6 | CAS number: 68187-29-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a (Q)SAR model, with limited documentation / justification, but validity of model and reliability of prediction considered adequate based on a generally acknowledged source
- Justification for type of information:
- The test material is a mixture of many substances. Comparison of all substances has shown that they are expected to have the same developmental toxicity. For the purpose of addressing the developmental toxicity endpoint the most concentrated component of the test material was assessed individually.
Cross-reference
- Reason / purpose for cross-reference:
- other: read-across target
Reference
- Endpoint:
- developmental toxicity
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- For the justification for read-across, please refer to the read-across assessment framework report that is attached to Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Dose descriptor:
- other: Reproductive toxicity potential.
- Based on:
- test mat.
- Basis for effect level:
- other: Not known precedent reproductive and developmental toxic potential.
- Remarks on result:
- not measured/tested
- Abnormalities:
- not specified
- Dose descriptor:
- other: Developmental toxicity potential.
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: Not known precedent reproductive and developmental toxic potential.
- Remarks on result:
- not measured/tested
- Abnormalities:
- not specified
- Developmental effects observed:
- not specified
- Treatment related:
- not specified
- Conclusions:
- Based on the modelled conditions, the developmental toxicity of the target chemical is predicted to be "Not known precedent reproductive and developmental toxic potential".
- Executive summary:
The potential of the component present at the highest concentration in the test material to cause developmental toxicity was modelled using the DART QSAR model in the OECD Toolbox. A prediction of "Not known precedent reproductive and developmental toxic potential" was obtained. It has been shown, using read across, that all components are expected to have the same toxicity. Therefore, the developmental toxicity of the target chemical is predicted to be "Not known precedent reproductive and
developmental toxic potential".
Toxicity of the target chemical (Not known precedent reproductive and developmental toxic potential) is predicted by QSAR "Developmental and Reproductive Toxicity (DART)". The current prediction has no applicability domain.
Data source
Reference
- Reference Type:
- other: QSAR Prediction
- Title:
- QSAR Toolbox prediction for single chemical.
- Author:
- Anon.
- Year:
- 2 018
- Bibliographic source:
- OECD QSAR Toolbox v 4.2
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on QSARs R.6. May/July 2008
- Principles of method if other than guideline:
- This QSAR model is based on profiling results obtained by DART scheme v 1.0. This QSAR is used for identifying chemicals with structural features associated with the potential to act as reproductive or developmental toxicants. The outcome of the QSAR model is “Known precedent reproductive and developmental toxic potential”, if the chemical has a potential to cause toxicity. The corresponding category is displayed in the report generated for the obtained prediction. The other prediction results are “Not known precedent reproductive and developmental toxic potential” if the toxic potential of the input chemical is not known, and “Not covered by current version of the decision tree” if the identified structural features are not objects of the tree.
- GLP compliance:
- no
- Remarks:
- As no laboratory work took place, compliance with GLP is not required.
Test material
- Reference substance name:
- L-Glutamic acid, N-coco acyl derivs., compds. with triethanolamine (1:1)
- EC Number:
- 269-084-6
- EC Name:
- L-Glutamic acid, N-coco acyl derivs., compds. with triethanolamine (1:1)
- Cas Number:
- 68187-29-1
- Molecular formula:
- Not specified (UVCB substance)
- IUPAC Name:
- bis(tris(2-hydroxyethyl)azanium) (2S)-4-carboxy-2-dodecanamidobutanoate (2S)-4-carboxy-2-tetradecanamidobutanoate
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- SMILES: OCC[N+H](CCO)CCO.CCCCCCCC(=O)NC(CCC(O)=O)C([O-])=O
Test animals
- Species:
- other: QSAR; species not specified
Results and discussion
Results: maternal animals
Effect levels (maternal animals)
- Dose descriptor:
- other: Reproductive toxicity potential
- Based on:
- test mat.
- Basis for effect level:
- other: Not known precedent reproductive and developmental toxic potential
- Remarks on result:
- not measured/tested
Maternal abnormalities
- Abnormalities:
- not specified
Results (fetuses)
Effect levels (fetuses)
- Dose descriptor:
- other: Developmental toxicity potential
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: Not known reproductive and developmental toxic potential
- Remarks on result:
- not measured/tested
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
- Treatment related:
- not specified
Any other information on results incl. tables
Toxicity of the target chemical (Not known precedent reproductive and developmental toxic potential) is predicted by QSAR "Developmental and Reproductive Toxicity (DART)". The current prediction has no applicability domain.
Applicant's summary and conclusion
- Conclusions:
- Toxicity of the target chemical was predicted by QSAR "Developmental and Reproductive Toxicity (DART)". The target chemical was predicted to fall under the category "Not known precedent reproductive and developmental toxic potential".
- Executive summary:
The potential of the test material to cause reproductive or developmental toxicity was modelled using the OECD QSAR Toolbox. This QSAR model is based on profiling results obtained by DART scheme v 1.0. This QSAR is used for identifying chemicals with structural features associated with the potential to act as reproductive or developmental toxicants.
Toxicity of the target chemical was predicted by QSAR "Developmental and Reproductive Toxicity (DART)". The target chemical was predicted to fall under the category "Not known precedent reproductive and developmental toxic potential".
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.