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EC number: 203-430-9 | CAS number: 106-75-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 36 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 59 mg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 7 mg/L
- Assessment factor:
- 50
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 200 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 28 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 5.7 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 1.5 mg/kg soil dw
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
Derivation of PNECs
Oxydiethylene bis(chloroformate) rapidly hydrolyses in contact with water to form diethylene glycol (CAS 111-46-6), hydrogen chloride (CAS 7647-01-0) and carbon dioxide (CAS 124-38-9). Effect values of the hydrolysis product hydrogen chloride were not considered in the derivation of the PNECs since the observed toxicity was not due to the intrinsic properties of the molecule but rather to pH effects. For the hydrolysis product carbon dioxide no ecotoxicological information is available. Therefore, only the results obtained from tests with the parent substance and the hydrolysis product diethylene glycol are considered for derivation of PNECs.
In the study with the parent substance isopropyl chloroformate rapid hydrolysis to isopropanol and hydrogen chloride may be expected to have occurred. However, remarkably the toxicity in the study with oxydiethylene bis(chloroformate) is considerably higher than the toxicity observed in the study with the hydrolysis product diethylene glycol. Considering that the pH remained within acceptable limits (i.e. no effects expected to be related to the formation of hydrogen chloride), the clearly higher toxicity of oxydiethylene bis(chloroformate) may be expected to be due to reactivity of un-hydrolysed parent substance at the beginning of the test. On a larger geographical and temporal scale oxydiethylene bis(chloroformate) may be expected to exist in aqueous environments mainly, if not only, as its hydrolysis products and therefore the short-term reactivity effect is considered likely to be of little relevance for environmental assessment. Therefore, the PNECs have been derived based on data available for diethylene glycol.
Conclusion on classification
Official classification regarding environmental hazards (relating to Oxydiethylene bis(chloroformate) (CAS 106-75 -2))
Aquatic compartment
In accordance with Regulation (EC) 1272/2008 Annex VI Table 3.1: N, R51/53
In accordance with Regulation (EC) 1272/2008 Annex VI Table 3.2: GHS09, chronic 2 (H411)
Self-classification (relating to diethylene glycol (CAS 111-46-6))
Aquatic compartment
Acute (short-term) aquatic hazard
Following CLP, the substance is not to be classified as acutely hazardous to the aquatic environment.
Rationale:
The substance is not to be classified as acutely hazardous to the aquatic environment, since all the lowest acute effect value of the three trophic levels are > 1 mg/L.
Long-term aquatic hazard
Following CLP, the substance is not to be classified as chronically hazardous to the aquatic environment.
Rationale:
- Chronic toxicity data: The substance is rapidly degradable and the lowest chronic effect value is > 1 mg/L (CoRAP Evaluation Report: NOEC = 365 mg/L). According to the criteria outlined in Table 4.1.0(b) (ii) (Commission Regulation (EU) No 286/2011 amending Regulation (EC) No 1272/2008) the substance is not to be classified as chronically hazardous to the aquatic environment.
- Acute toxicity data: The lowest EC50 was determined for algae (EC50 > 100 mg/L), the substance is rapidly degradable and the log Pow is < 4. According to the criteria outlined in Table 4.1.0(b) (iii) (Commission Regulation (EU) No 286/2011 amending Regulation (EC) No 1272/2008) the substance is not to be classified as chronically hazardous to the aquatic environment.
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