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EC number: 200-389-9 | CAS number: 58-61-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 2003
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- not applicable
- Principles of method if other than guideline:
- Respirometric degradation and toxicity test (ready biodegradability)
- GLP compliance:
- no
Test material
- Reference substance name:
- Adenosine
- EC Number:
- 200-389-9
- EC Name:
- Adenosine
- Cas Number:
- 58-61-7
- Molecular formula:
- C10H13N5O4
- IUPAC Name:
- adenosine
- Test material form:
- solid
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- - Source: ARA Reinach (5 times washed)
- Concentration of sludge: 30 mg/L dry matter - Duration of test (contact time):
- ca. 28 d
Initial test substance concentration
- Initial conc.:
- ca. 89.8 mg/L
- Based on:
- other: nominal test item concentration based on 100 mg ThOD/L
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST SYSTEM
- Test performed in triplicate (three test flasks)
CONTROL AND BLANK SYSTEM
BL (blank)
NaB – BL (Natriumbenzoate minus blank)
TES- BL (test item minus blank)
TOX – TES (toxicity control)
PHY (sterile control)
TES- BL (NO2, NO3 determined)
MEASUREMENTS
Samples were taken every 6 h.
Reference substance
- Reference substance:
- other: Sodium benzoate CAS 532-32-1
Results and discussion
- Preliminary study:
- none
% Degradation
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- ca. 100
- Sampling time:
- 28 d
Any other information on results incl. tables
Results after 28 d, mean values
Vessel |
mg/l O2 |
± mg/l |
BL (blank) |
32.5 |
3.5 |
NaB – BL (sodium benzoate minus blank) |
158.2 |
4.8 |
TES- BL (test item minus blank) |
204.5 |
12.6 |
TOX – TES (toxicity control) |
131.4 |
1.2 |
PHY (sterile control) |
3.4 |
0.3 |
TES- BL (NO2, NO3 determined) |
204.5 |
12.6 |
The degradation curve obtained with the reference substance confirmed the suitability of inoculum and test conditions.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Interpretation of results:
- readily biodegradable
- Conclusions:
- A 28-d ready biodegradability test (Respirometry Test similar to guideline OECD 301 F) using activated sludge of a municipal sewage treatment plant indicated that adenosine (CAS 58-61-7) reached 100% degradation. The pass level of 60% for ready biodegradability as defined in test guideline OECD 301 was reached within the 10-d window and, therefore, the substance can be termed as readily biodegradable.
- Executive summary:
A 28-d ready biodegradability test (Respirometry Test similar to guideline OECD 301 F) using activated sludge of a municipal sewage treatment plant indicated that adenosine (CAS 58-61-7) reached 100% degradation. The pass level of 60% for ready biodegradability as defined in test guideline OECD 301 was reached within the 10-d window and, therefore, the substance can be termed as readily biodegradable.
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