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EC number: 609-221-2 | CAS number: 3625-46-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- August 2001
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 431 (In Vitro Skin Corrosion: Human Skin Model Test)
- Principles of method if other than guideline:
- - Principle of test: in-vitro test
- Short description of test conditions: A concentration of 100% of the test substance was used at pH of 7. No direct MTT reduction was obseved for the test substance.
- Parameters analysed: The Optical Density (OD) at a wavelength of 570 nm was tested and the viability calculated according to the results obtained. - GLP compliance:
- no
Test material
- Reference substance name:
- 3,7,11-trimethyldodec-1-en-3-ol
- EC Number:
- 609-221-2
- Cas Number:
- 3625-46-5
- Molecular formula:
- C15H30O
- IUPAC Name:
- 3,7,11-trimethyldodec-1-en-3-ol
- Test material form:
- liquid
- Details on test material:
- Tetrahydronerolidol (THNER)
CAS No. 3625-46-5
Batch No.: Anlage 067, 13 Jun 2001
Purity: 96 %
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Batch No.of test material: Anlage 067, 13.06.01
- Substance number: 01/0405-1
In vitro test system
- Justification for test system used:
- With the EpiDerm Corrosivity Test the corrosivity of test articles can be determined.
- Vehicle:
- unchanged (no vehicle)
- Details on test system:
- Two tissues were used
- Control samples:
- yes, concurrent negative control
- Amount/concentration applied:
- TEST MATERIAL
- Concentration: 100% - Duration of treatment / exposure:
- Exposure: 3 min and 1 h
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- % tissue viability
- Run / experiment:
- Exposure after 3 min and 1 h
- Value:
- > 94 - < 98
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Any other information on results incl. tables
The viability after 3 min and 1 h exposure of the
undiluted test substance was 94 % and 98 %, respectively.
The viability after 3 min and 1 h exposure of the positive control was 8
% and 8 %, respectively.
Exposure time: 3 min.
tissue 1 tissue 2 mean OD viability
(570 nm) (570 nm) (570nm) [% of NC]
---------------------------------------------------
NC 1.884 1.864 1.874 100
TS 1.790 1.725 1.758 94
PC 0.149 0.166 0.157 8
NC = negative control
TS = test substance
PC = positive control
Exposure time: 1 hour
tissue 1 tissue 2 mean OD viability
(570 nm) (570 nm) (570nm) [% of NC]
---------------------------------------------------
NC 2.241 2.110 2.176 100
TS 2.146 2.108 2.127 98
PC 0.123 0.195 0.159 8
NC = negative control
TS = test substance
PC = positive control
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- The test substance did not show effects in the EpiDerm Corrosivity-Test in vitro and thus, it was concluded that the test substance does not induce severe skin irritation. However, possible skin irritancy cannot be evaluated in this test system.
- Executive summary:
The EpiDerm Corrosivity-Test in vitro was used to assess the potential to induce severe skin irritations of the test substance at a concentration of 100% (undiluted). Exposure times were set to three minutes and one hour. No direct MTT reduction was observed. The viability was analyzed with optical density at 570 nm. The test substance generated a viability of 94% and 98% after three minutes and one hour exposure, respectively. The negative and the positive control revealed valid results of 100% and 8%, respectively, both after three minutes and one hour exposure.
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