Registration Dossier
Registration Dossier
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EC number: 242-980-4 | CAS number: 19351-18-9
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016-01-06 till 2016-03-14
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study without restrictions.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- (adopted, May 2008)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- (adopted July 1995)
- Deviations:
- no
- Principles of method if other than guideline:
- The water solubility is determined using the flask method according to OECD Guideline 105, EC Guideline A.6. In a preliminary test a water solubility of 2,2-Dimethyl-thiazolidine in each ratio was observed. Therefore solubility tests in ratios 1+10, 1+1 and 10+1 of 2,2-Dimethylthiazolidine in demineralized water are prepared.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Temp.:
- 20 °C
- Remarks on result:
- other: Soluble in demineralized water in each ratio (1+10, 1+1, 10+1)
- Conclusions:
- The results of the tests shows, that 2,2-Dimethylthiazolidine was soluble in demineralized water (20 °C) in each ratio (1+10, 1+1, 10+1).
- Executive summary:
The determination of the water solubility of 2,2 -Dimethylthiazolidine was measured according OECD guideline 105 “Water solubility“ (adopted 27th July 1995) and EC guideline A.6 “Water solubility” (adopted, May 2008).
The results of the tests shows, that 2,2-Dimethylthiazolidine was soluble in demineralized water (20 °C) in each ratio (1+10, 1+1, 10+1).
Reference
Initial weights and volumes of 2,2-Dimethylthiazolidine
| Test at 20 °C | Flask 1 | Flask 2 | Flask 3 |
| Ratio 1 + 10 | Ratio 1 + 1 | Ratio 10 + 1 | |
| Initial weight of the test item [g] | 1.06 | 4.99 | 9.99 |
| Volume of demineralized water in [g] | 10.07 | 5.02 | 0.99 |
| Appearance | Clear solution | Clear solution | Clear solution |
Result:
The results of the tests shows, that 2,2-Dimethylthiazolidine was soluble in demineralized water in each ratio. Therefore no more tests for the water solubility of the test item were necessary.
Description of key information
The results of the tests shows, that 2,2-Dimethylthiazolidine was soluble in demineralized water of 20 °C in each ratio (1+10, 1+1, 10+1).
Key value for chemical safety assessment
Additional information
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