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EC number: 216-509-8 | CAS number: 1604-34-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- 1996
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Version / remarks:
- 1998
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Version / remarks:
- 1996
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Experimental Toxicology and Ecology BASF Aktiengesellschaft
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 6,10-dimethylundecan-2-one
- EC Number:
- 216-509-8
- EC Name:
- 6,10-dimethylundecan-2-one
- Cas Number:
- 1604-34-8
- Molecular formula:
- C13H26O
- IUPAC Name:
- 6,10-dimethylundecan-2-one
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): Tetrahydrogeranylaceton
- Substance No.: 01/0275-1
- Batch-Nr.: B 633
- Purity: 97.5 area% (GC)
- Date of production: 17 Oct 2000
- Substance type: Liquid / colourless - clear
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: BASF, Batch No. B633
- Date of production: 2000-10-17
- Purity: 97.49 FI.-% (GC)
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: refrigerator
- Stability under test conditions: The stability of the test substance over the study period was confirmed by analysis.
- Homogeneity: homogeneous
- Physical state / appearance: liquid / colourless - clear
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: The test substance preparation was produced for each dose group shortly before administration in olive oil Ph.Eur./DAB by stirring with a magnetic stirrer.
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Strain: Wistar / CrIGlxBrIHan:WI
- Source: Charles River Deutschland GmbH, Sandhofer Weg 7, 97633 Sulzfeld
- Animal identification: Individual identification by cage cards and tail marking
- Age at study initiation: Young adult animals (male animals approx. 8 - 12 weeks, female animals approx. 14 -18 weeks)
- Weight at study initiation: mean 231 g (male), 192 g (female)
- Fasting period before study: Feed was withdrawn from the animals at least 16 hours before administration, but water was available ad libitum.
- Housing: single housing in stainless steel wire mesh cages, type DK-111 (Becker & Co., Castrop-Rauxel, FRG)
- Diet (e.g. ad libitum): Kliba-Labordiät, Provimi Kliba SA, Kaiseraugst, Switzerland, ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation period: at least 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24
- Humidity (%): 30 - 70
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 40g/100 ml
- Amount of vehicle (if gavage): 5 ml/kg bw
- Justification for choice of vehicle: Olive oil Ph.Eur/DAB had to be used to ensure homogeneityof the preparation.
MAXIMUM DOSE VOLUME APPLIED: 5 ml/kg bw
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: Based on the physical and chemical characteristics of the test substance and its composition, no pronounced acute oral toxicity was expected. Therefore, a starting dose of 2,000 mg/kg body weight (limit test) has been chosen in the first step with 3 female animals. As none of those animals died, 2,000 mg/kg body weight were administered to 3 male animals in a second step. Because no mortality occurred either the study fulfilled the criteria for a limit test and was terminated. - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Individual body weights shortly before administration (day 0), weekly thereafter and at the end of the study.
- Recording of signs and symptoms several times on the day of administration: at least once each workday for the individual animals
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight; Recording of signs and symptoms several times on the day of administration, at least once each workday for the individual animals
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other:
- Remarks:
- no mortality observed
- Mortality:
- No mortality noted
- Clinical signs:
- Signs of toxicity noted in the females of the 2,000 mg/kg dose group comprised poor general state, dyspnoea, apathy and piloerection and were observed during hour 5 after administration.
- Body weight:
- The mean body weights of the dose groups increased throughout the study period.
- Gross pathology:
- No macroscopic pathologic abnormalities were noted in the animals (3 males and 3 females) examined at termination of the study.
Any other information on results incl. tables
Body weight:
The mean body weights of the dose groups increased throughout the study period.
Mean body weight during the observation period:
male (g) female (g)
---------------------------------------
day 0 231 197
day 7 260 212
day 14 289 218
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of the study the median lethal dose of the test substance after oral administration was found to be greater than 2.000 mg/kg body weight for male and female rats.
- Executive summary:
The study was performed to assess the acute toxicity following oral administration of the test substance in Wistar rats.
The study procedure was based on the OECD, EU and US EPA OPPTS guidelines.
Single doses of 2.000 mg/kg body weight of test material preparations in olive oil Ph.Eur./DAB were given to two dose groups of three fasted animals, each (males and females) by gavage in a sequential manner.
No mortality occured.
Clinical signs and findings in the female dose group comprised poor general state, dyspnoea, apathy and piloerection. Findings were observed during hour 5 after administration. No signs of toxicity were observed in the male dose group.
The mean body weights of the dose groups increased throughout the study period.
No macroscopic pathologic abnormalities were noted in the animals examined at the end of the observation period.
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