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Diss Factsheets
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EC number: 422-030-7 | CAS number: 91538-82-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20.10. - 17.11.2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- 2001
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- sewage sludge
- Radiolabelling:
- no
- Test temperature:
- 25 °C
- Details on study design: HPLC method:
- HPLC equipment: HPLC System and variable wavelength detector
Column: Stationary phase cyanopropyl solid phase
Mobile phase: Methanol/distilled water - Analytical monitoring:
- not required
- Key result
- Type:
- log Koc
- Value:
- 4.97 dimensionless
- Temp.:
- 25 °C
- Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption coefficient of the lest item was determined according to the "HPLC- method" described in guideline OECD 121. The adsorption coefficient of the test item was found to be:Log Koc = 4.97
- Executive summary:
A study was conducted in accordance with OECD 121 and67/548/EEC annex C.19. to determine theadsorption coefficient of the test substance using the HPLCmethod. The adsorption coefficient of the test substance was derived from its retention time and the calibration graph. The retention time of the test item was above the retention time of the highest calibration standard (log Koc) and thus out of the calibration range. Therefore, the dsorption coefficient of the test substance was determined to be above 4.2 and estimated to be Log Koc=4.97.
Reference
Table 1: Determination of the dead time t0
Dead time marker |
tR/min 1stinjection |
tR/min 2ndinjection |
tR/min 3rdinjection |
Formamide |
3.425 |
3.426 |
3.426 |
dead time t0=3.426 min
Table 2: Calibration data 1stinjection
Calibration substance |
tR/min |
k |
Log k |
Log Koc |
Acetanilide |
3.924 |
0.15 |
-0.84 |
1.25 |
Phenole |
3.887 |
0.13 |
-0.87 |
1.32 |
Atrazin |
4.034 |
0.18 |
-0.75 |
1.81 |
Monuron |
4.213 |
0.23 |
-0.64 |
1.99 |
Triadimenol |
4.346 |
0.27 |
-0.57 |
2.40 |
Linuron |
4.724 |
0.38 |
-0.42 |
2.59 |
Pyrazophos |
5.395 |
0.57 |
-0.24 |
3.65 |
Diclofop-methyl |
5.665 |
0.65 |
-0.18 |
4.20 |
Regression: log Koc= a+ b · log k
Parameters: a=-4.64, b=3.98, r2=0.9632
Table 3: Log Kocof the test item 1stinjection
|
tR/min |
k |
Log k |
Log Koc |
Test item |
7.565 |
1.21 |
0.08 |
4.97 />4.20*) |
*beyond log Koc value of the highest calibration substance (Diclofop-methyl)
Table 4: Calibration data 2ndinjection
Calibration substance |
tR/min |
k |
Log k |
Log Koc |
Acetanilide |
3.926 |
0.15 |
-0.84 |
1.25 |
Phenole |
3.887 |
0.13 |
-0.87 |
1.32 |
Atrazin |
4.037 |
0.18 |
-0.75 |
1.81 |
Monuron |
4.213 |
0.23 |
-0.64 |
1.99 |
Triadimenol |
4.347 |
0.27 |
-0.57 |
2.40 |
Linuron |
4.726 |
0.38 |
-0.42 |
2.59 |
Pyrazophos |
5.396 |
0.58 |
-0.24 |
3.65 |
Diclofop-methyl |
5.666 |
0.65 |
-0.18 |
4.20 |
Regression: log Koc= a+ b · log k
Parameters: a =4.64, b =3.98, r2=0.9632
Table 5: Log Powof the test item 2ndinjection
|
tR/min |
k |
Log k |
Log Koc |
Test item |
7.565 |
1.21 |
0.08 |
4.97 / >4.20* |
*beyond log Koc value of the highest calibration substance (Diclofop-methyl)
Within two injections, theadsorption coefficientKocof the test item was determined to be:
Log Koc=>4.97
Description of key information
Key value for chemical safety assessment
- Koc at 20 °C:
- 4.97
Additional information
A study was conducted in accordance with OECD 121 and 67/548/EEC annex C.19. to determine theadsorption coefficient of the test substance using the HPLCmethod. The adsorption coefficient of the test substance was derived from its retention time and the calibration graph. The retention time of the test item was above the retention time of the highest calibration standard (log Koc 4.2) and thus out of the calibration range. Therefore, the adsorption coefficient of the test substance was determined to be above 4.2 and estimated to beLog Koc= 4.97
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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