Registration Dossier
Registration Dossier
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EC number: 216-706-9 | CAS number: 1646-26-0
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2 to 3 March 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- 2004
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Swiss Federal Office of Public Health, Bern, Switzerland
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 1.94
- Temp.:
- 20 °C
- Remarks on result:
- other: pH not measured or not reported.
- Conclusions:
- A partition coefficient value of 1.94 (at 20 °C) was determined for the test substance according to OECD 117.
Reference
The R² fit of the calibration curve used was 0.986. The deviations of calculated Log POW-values from actual ones were 8.8 % at maximum. This reflects the linear correlation between the logarithms of the capacity factors of the HPLC system and the Log POW-values of the reference items in the applied range of 0.5 to 3.4.
The following table summarizes the results obtained for the test item.
Test Item |
Retention Time [min] |
Log k' |
Log POW |
Mean |
Overall Mean |
|
Solution 1 |
1strun |
2.700 |
0.0625 |
1.951 |
1.95 |
1.94 ± 0.00 |
2ndrun |
2.700 |
0.0580 |
1.943 |
|||
Solution 2 |
1strun |
2.700 |
0.0580 |
1.943 |
1.94 |
|
2ndrun |
2.700 |
0.0580 |
1.943 |
|||
Conclusion
During this study, the partition coefficient (n-octanol/water) of the test item was determined using the HPLC method. The Log POW-value of the test item was found to be 1.94.
Description of key information
Log Kow: 1.94 at 20 °C (OECD Guideline 117, HPLC method)
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.94
- at the temperature of:
- 20 °C
Additional information
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