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Diss Factsheets
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EC number: 283-815-6 | CAS number: 84731-55-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.172 mg/cm²
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 5
- AF for intraspecies differences:
- 5
- Justification:
- Standard worker AF
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
Inhalation toxicity
The substance has not been tested by the inhalation route. Lithium isooctadecanoate is exclusively produced and used directly in grease form. It has a vapour pressure of less than 10 E-10 Pa and a melting point of 193°C, so the potential for the generation of inhalable forms is low, also the use of the grease forms will not result in aerosols, particles or droplets of an inhalable size, so exposure to humans via the inhalatory route will be unlikely to occur. However, although no substance specific intrinsic inhalative toxicity is expected, generally accepted OELs derived for inert (nuisance) dust/particulates not otherwise classified (PNOCs) of 10 mg/m3 for chronic and 20 mg/m3 for acute exposure to inhalable dust and of 3 mg/m3 for chronic and of 6 mg/m3 for acute exposure to alveolar (respirable) dust are applicable and must be adhered to, to avoid non-specific inhalative dust toxicity. By adherence to the general dust limits, the risk to humans can be considered to be sufficiently controlled. In accordance with ECHA REACH TGD R.8, the general dust limits are used as DNEL surrogate. Therefore, lithium isooctadecanoate is not considered to be hazardous.
Dermal toxicity
There are no data available for lithium isooctadecanoate. However, a combined short-term repeat dose and reproductive toxicity screening study via dermal route was conducted on fatty acids C18 -(unsaturated) lithium salts and the results have been read across to lithium isooctadecanoate. Data on fatty acids C18 (unsaturated) lithium salts are considered to be appropriate for read across on the basis that the two substances have common structures of a lithium salt of C18 fatty acids. Lithium isooctadecanoate has a single methyl branch while fatty acids C18 (unsaturated) lithium salts contains unsaturated carbon-carbon double bonds. See IUCLID section 13 for read across justification.
Fatty acids C18 (unsaturated) lithium salts is a UVCB substance consisting of C18 fatty acids with a range of degrees of unsaturation. Although a molecular weight has not been specified, as a lithium salt of C18 fatty acids, the molecular weight is expected to be comparable to that of lithium isooctadecanoate, varying by only a few hydrogens. Therefore, no calculations have been applied to convert the toxicity values which have been read across between the substances.
The experimental results from the repeated dose dermal toxicity study on fatty acids C18 (unsaturated) lithium permits consideration of long term local effects on the skin. The NOAEL for this effect was 111.25 mg/kg/day, which converts to 0.86 mg/cm2 based on the area of rat skin exposed in the subacute study (average weight of the rats in the study was 311g, the body surface area was calculated as being approximately 9.1 x bw(g)0.66, and the approximate surface area exposed was 10%).Using a standard worker assessment factor of 5, the DNEL was calculated to be 0.172 mg/cm2.
No systemic effects were observed at the highest dose of fatty acids C18 -(unsaturated) lithium salts tested so the NOAEL was determined to be 1089.75 mg/kg bw/day.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.086 mg/cm²
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- AF for intraspecies differences:
- 10
- Justification:
- Standard AF for general population
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Inhalation toxicity
The substance has not been tested by the inhalation route. Lithium isooctadecanoate is exclusively produced and used directly in grease form. It has a vapour pressure of less than 10 E-10 Pa and a melting point of 193°C, so the potential for the generation of inhalable forms is low, also the use of the grease forms will not result in aerosols, particles or droplets of an inhalable size, so exposure to humans via the inhalatory route will be unlikely to occur. However, although no substance specific intrinsic inhalative toxicity is expected, generally accepted OELs derived for inert (nuisance) dust/particulates not otherwise classified (PNOCs) of 10 mg/m3 for chronic and 20 mg/m3 for acute exposure to inhalable dust and of 3 mg/m3 for chronic and of 6 mg/m3 for acute exposure to alveolar (respirable) dust are applicable and must be adhered to, to avoid non-specific inhalative dust toxicity. By adherence to the general dust limits, the risk to humans can be considered to be sufficiently controlled. In accordance with ECHA REACH TGD R.8, the general dust limits are used as DNEL surrogate. Therefore, lithium isooctadecanoate is not considered to be hazardous.
Dermal toxicity
There are no data available for lithium isooctadecanoate. However, a combined short-term repeat dose and reproductive toxicity screening study via dermal route was conducted on fatty acids C18 -(unsaturated) lithium salts and the results have been read across to lithium isooctadecanoate. Data on fatty acids C18 (unsaturated) lithium salts are considered to be appropriate for read across on the basis that the two substances have common structures of a lithium salt of C18 fatty acids. Lithium isooctadecanoate has a single methyl branch while fatty acids C18 (unsaturated) lithium salts contains unsaturated carbon-carbon double bonds. See IUCLID section 13 for read across justification.
Fatty acids C18 (unsaturated) lithium salts is a UVCB substance consisting of C18 fatty acids with a range of degrees of unsaturation. Although a molecular weight has not been specified, as a lithium salt of C18 fatty acids, the molecular weight is expected to be comparable to that of lithium isooctadecanoate, varying by only a few hydrogens. Therefore, no calculations have been applied to convert the toxicity values which have been read across between the substances.
The experimental results from the repeated dose dermal toxicity study on fatty acids C18 (unsaturated) lithium permits consideration of long term local effects on the skin. The NOAEL for this effect was 111.25 mg/kg/day, which converts to 0.86 mg/cm2 based on the area of rat skin exposed in the subacute study (average weight of the rats in the study was 311g, the body surface area was calculated as being approximately 9.1 x bw(g)0.66, and the approximate surface area exposed was 10%). Using a standard general population assessment factor of 10, the DNEL was calculated to be 0.086 mg/cm2.
No systemic effects were observed at the highest dose of fatty acids C18 -(unsaturated) lithium salts tested so the NOAEL was determined to be 1089.75 mg/kg bw/day.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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