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EC number: 947-057-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
OECD Guideline 203, GLP, key study, validity 2:
Acute toxicity to fish: LC50(96h) > 100 mg/L
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 100 mg/L
Additional information
To assess the short-term toxicity of the registered substance to fish, three studies are available.
A study (DHI, 2002) was performed to assess the acute toxicity of the test item to Danio rerio,under semi-static conditions according to OECD Guideline 203: the test item appeared as white creamy liquid and it caused no mortality in the tested concentrations (0.1, 0.3, 1.0, 3.0 and 10 mg/L) during the 96 hour period. Under the test conditions, the 24, 48, 72 and 96 h LC50 value was higher than 10 mg/L (nominal concentration) and no mortality was observed in fish up to 10 mg/L (the maximum concentration tested). This study was considered as a supporting study of reliability 2. The second reliable study was performed by Sewell (1993) to assess the acute toxicity of the test item to rainbow trout Oncorhynchus mykiss,according to OECD Guideline 203. There were no mortalities or other adverse reactions to exposure in 20 fish exposed to a test concentration of 100 mg/L for a period of 96 hours. Highest test concentration resulting in 0% mortality is ≥ 100 mg/L. This study was considered as a key study of reliability 2.
The third study from Boer (1990) assessed the acute toxicity of the test item to Poecilia reticulata similarly to OECD Guideline 203. Under the test conditions, the 24, 48, 72 and 96 h LC50 value was > 10 to < 18 mg/L (nominal concentration). No effects were found in this study up to a concentration of 5.6 mg/L at 96 h. No indications are provide of how test solutions were prepared and whether they were clear. The mortality oberved in this study at concentrations >5.6 mg/L are considered to be in strict contrast with the two other fish studies where no mortality was observed at 10 mg/L (maximum concentration tested) and 100 mg/L. Moreover, no effects were observed on other species either. An explanation for this was therefore sought:
Studies on fish (DHI, 2002), daphnia (Adema, 1980) and algae (SafePharm,2003) included in this dossier report that the solutions with akypoquat 131 appear as white creamy liquid between 0.1 and 10 mg/L (fish test), whitish turbid from 0.32 to 320 mg/L (daphnia) and very slightly cloudy with homogenous dispersions at 100 mg/L (algae). Based on these observations, the critical micelle concentration is expected to be lower than 10 mg/L. This is supported by a specific study on CMC of the registered substance where this value was determined as <1 mg/L. It is generally considered that effects of surfactants at concentrations greater than the CMC should be treated with caution as bioavailability of the test substance does not increase beyond this concentration and there is a risk of physical effects. As a consequence the no effect concentrations up to a value of 5.6 mg/L observed in the third study (Boer, 1990) should be considered while the LC50 (96h) > 10 to < 18 mg/L (nominal concentration) from this study should be disregarded as >CMC and due to physical effects.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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