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EC number: 204-376-9 | CAS number: 120-20-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Justification for type of information:
- data is from experimental reports
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- The skin irritation potential of 4-methoxybenzyl alcohol / Anisic alcohol (CAS No: 105-13-5) was assessed in guinea pigs via Open Epicutaneous test (OET).
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-methoxybenzyl alcohol
- EC Number:
- 203-273-6
- EC Name:
- 4-methoxybenzyl alcohol
- Cas Number:
- 105-13-5
- Molecular formula:
- C8-H10-O2
- IUPAC Name:
- (4-methoxyphenyl)methanol
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): 4-methoxybenzyl alcohol
-Molecular Formula: C8H10O2
- Molecular Weight: 138.165 g/mol
- Substance type: Organic
- Physical state: Liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 4-methoxybenzyl alcohol
-Molecular Formula: C8H10O2
- Molecular Weight: 138.165 g/mol
- Substance type: Organic
- Physical state: Liquid
Test animals
- Species:
- guinea pig
- Strain:
- not specified
Test system
- Type of coverage:
- open
- Preparation of test site:
- other: clipped flank
- Vehicle:
- other: acetone
- Controls:
- yes
- Amount / concentration applied:
- 60, 30, 10 and 3 %
- Duration of treatment / exposure:
- 21 days
- Observation period:
- after a single application or after repeated application over 21 successive days
- Number of animals:
- 6-8
- Details on study design:
- One day before starting the induction procedure, the threshold-toxic concentration of the test material is estimated. A single application of 0.025 ml of each test concentration (e.g. 100, 30, 10 and 3%) is simultaneously performed on one of the areas measuring 2cm2 of the flank skin previously clipped and marked with a circular stamp.
The skin reactions are read 24 hours after the application of the test material. The minimal irritant and the maximal non-irritant concentrations are determined by an all-or-none criterion. The minimal irritant concentration is defined as the lowest one causing skin irritation. The maximal non-irritant concentration is defined as the highest one not causing macroscopic skin reactions in any of the animals. The estimation of the threshold concentration (minimal irritating and maximal non-irritating concentrations) is essential for the evaluation of the allergenic capacity of the test material based on the end point determination.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: Highest non irritant
- Basis:
- mean
- Time point:
- 24 h
- Reversibility:
- not specified
- Remarks on result:
- other: 3% solution of the substance
- Irritation parameter:
- other: Lowest irritant
- Basis:
- mean
- Time point:
- other: 24 hr
- Reversibility:
- not specified
- Remarks on result:
- other: 10% solution of the substance
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: day 7, 14 and 21
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- slight irritation was observed.
Any other information on results incl. tables
After repeated application over 21 successive days
Concentration % |
Skin irritation after days |
||
7 |
14 |
21 |
|
60 |
(+) |
+ |
+ |
30 |
(+) |
+ |
+ |
10 |
(+) |
(+) |
(+) |
3 |
- |
(+) |
(+) |
Degree of skin irritation:
- = none
(+) = very slight
+ = slight
++ = moderate
+++ = strong
++++ = very strong
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- A single application of Anisyl alcohol (4-methoxybenzyl alcohol) 3% in acetone is well tolerated. Repeated applications cause very slight skin irritation only. The highest concentration of the preparation used for this treatment was 60%. Hence the chemical 4-methoxybenzyl alcohol / Anisic alcohol (CAS No: 105-13-5) was considered as irritating to the skin og guinea pigs.
- Executive summary:
The skin irritation potential of 4-methoxybenzyl alcohol / Anisic alcohol (CAS No: 105-13-5) was assessed in guinea pigs via Open Epicutaneous test (OET).
The 0.025ml of chemical was applied at different concentrations (60, 30, 10 and 3 %) to an area measuring 2cm2previously marked with a circular stamp on the clipped flanks in of 6 to 8 animals under non-occlusive condition.
Skin reactions were evaluated after 24 hours of application and on day 7, 14 and 21.
A single application of Anisyl alcohol (4-methoxybenzyl alcohol) 3% in acetone is well tolerated. Repeated applications cause very slight skin irritation only. The highest concentration of the preparation used for this treatment was 60%.
Hence the chemical 4-methoxybenzyl alcohol / Anisic alcohol (CAS No: 105-13-5) was considered as irritating to the skin on guinea pigs.
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