Registration Dossier
Registration Dossier
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EC number: 214-202-3 | CAS number: 1113-38-8
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04 Nov - 06 Nov 2015
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other:
- Remarks:
- Due to very low lipophilicity study could not be conducted according to OECD guidelines for this endpoint. Instead lipophilicity was tested by determination of solubilities in water and n-octanol seperately. The study was conducted according to EU Method A.6. (Water Solubility) and OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- other: EU Method A.6 (Water Solubility)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: based on determination of ratio n-octanol solubility vs. aqueous solubility. Solubility determination accordingto OECD guideline 105, determination of octanol solubuility based on principle of OECD guideline 105.
- GLP compliance:
- no
- Type of method:
- other: based on determination of ratio n-octanol solubility vs. aqueous solubility. Solubiliyt determination accordingto OECD guideline 105, determination of octanol solubuility based on principle of OECD guideline 105.
- Partition coefficient type:
- octanol-water
- Analytical method:
- other: ion chromatography
- Type:
- log Pow
- Partition coefficient:
- < -4.8
- Temp.:
- 20 °C
- pH:
- 6.6
- Remarks on result:
- other: log Pow calculated by solubility (n-octanol)/solubility (water). Solubility (n-octanol) < 0.7mg/l
Reference
Measured n-Octanol solubility was < 0.7 mg/L at 20 °C for all 3 test series (after 24, 48, 72 hrs). Solubility of the test item in water was investigated by the study reported in reference 4.8 -1. It was determined as 41.8 g/L.
The partition coefficient n-octanol/water of the test substance was determined by individual solubilities in water and n-octanol. Solubilities were determined by the flask method as described in EU Method A.6 and OECD guideline 105. Log Pow of the test substance is smaller than -4.8
Description of key information
log POW < -4.8 at 20 °C (EU method A.8., flask method)
Key value for chemical safety assessment
Additional information
Partition coefficient was determined based on the ratio of the individual solubilities of the test item in water and octanol. The individual octanol solubility was determined using the flask method.
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