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Diss Factsheets
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EC number: 283-911-8 | CAS number: 84775-83-7 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Salvia sclarea, Labiatae.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Boiling point
Administrative data
Link to relevant study record(s)
- Endpoint:
- boiling point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 7 Mars to 29 Mars 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- The study was conducted according to an internationally recognised method, and under GLP. Substance ID is adequately specified. Therefore, full validation applies.
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 103 (Boiling point/boiling range)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.2 (Boiling Temperature)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- inspected on 13 and 14 October 2014 / signed on 08 April 2015
- Type of method:
- method according to Siwoloboff
- Key result
- Boiling pt.:
- 189.2 °C
- Atm. press.:
- 101.325 kPa
- Remarks on result:
- other: 189. 2 ± 0.4 °C (corresponding to 462.3 ± 0.4 K).
- Conclusions:
- The initial boiling temperature of the test item has been determined to be ca 189.2 ± 0.4 °C (462.3 ± 0.4 K), corrected to standard pressure (101.325 kPa).
- Executive summary:
The initial boiling point of the test item was measured under GLP according to OECD 103 / EU A2 guideline, by Siwoloboff. The test item was filled into a sample tube. The sample tube was then set into the aluminium block at 185.0 °C (first determination) and at 186.0 °C (second determination). For the increase of the temperature, a temperature gradient of 1 °C /min was maintained.When bubbles rose constantly on the capillary, heating was turned down, and, cooling slowly. The moment at which the chain of bubbles broke was recorded (with its atmospheric pressure) as boiling point .The determination was performed in duplicate.
The tinge of yellow was more intense after cooling down for each determination.
Reference
Observations and measured values are presented in the following table.
Table 4.3/1-Results
Determination |
Boiling Point |
Atmospheric Pressure |
First determination |
188.0 °C (461.2 K) |
99169 Pa |
Second determination |
188.5 °C (461.7 K) |
99161 Pa |
Table 4.3/2.-Observations
Observation |
First determination |
Second determination |
Boiling chain/ heating switched off |
220.0 °C / 221.6°C |
219.5 °C / 220.1°C |
After cooling down |
The tinge of yellow was more intense |
Corrected values following Sidney-Young: to calculate the boiling temperature at standard pressure (101.325kPa)
Table 4.3/3.-Corrected values to the standard presure 101.325kPa
|
Boiling point |
Pressure in Pa |
Corrected Boling point |
First determination |
188.0 °C (461.2 K) |
99169 Pa |
188.9 °C (462.0 K) |
Second determination |
188.5 °C (461.7 K) |
99161 Pa |
189.4 °C (462.5 K) |
Mean |
|
|
189.2 °C (462.3 K) |
Mean ± standard deviation (after correction following Sydney Young) = 189.2 ± 0.4 °C (462.3 ± 0.4 K) at standard pressure (101.325 kPa).
Description of key information
The initial boiling temperature of the test item has been determined to be ca 189. 1 ± 0.4 °C, corrected to standard pressure (101.325 kPa).
Key value for chemical safety assessment
- Boiling point at 101 325 Pa:
- 189.2 °C
Additional information
A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. It is considered as a key study.
The initial boiling point of the test substance was measured using the Siwoloboff method. The test item was filled into a sample tube. The sample tube was then set into the aluminium block at 185.0 °C (first determination) and at 186.0 °C (second determination). For the increase of the temperature, a temperature gradient of 1 °C /min was maintained. When bubbles rose constantly on the capillary, heating was turned down, and, cooling slowly. The moment at which the chain of bubbles broke was recorded (with its atmospheric pressure) as boiling point .The determination was performed in duplicate.
The tinge of yellow was more intense after cooling down for each determination.
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