Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 268-519-7 | CAS number: 68110-30-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: screening tests
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- The supporting QMRF report has been attached
- Guideline:
- other: 301C
- Principles of method if other than guideline:
- The prediction was done by using OECD QSAR tool box v3.3
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of the test chemical: 1,5-Naphthalenedisulfonic acid, 2,2'-[(2,2'-disulfo[1,1'-biphenyl]-4,4'-diyl)bis[imino (6-chloro-1,3,5-triazine-4,2-diyl)imino (1-hydroxy-3-sulfo-6,2-naphthalenediyl)azo]]bis-, octasodium salt
- Molecular formula: C58H38Cl2N14O26S8.8Na
- Molecular weight: 1850.3 g/mol
- Substance type: Organic
- SMILES : Oc1c2ccc(Nc3nc(Nc4ccc(-c5ccc(Nc6nc(Nc7ccc8c(c7)cc(S(=O)(=O)O{-}.[Na]{+})c(/N=N/c7ccc9c(S(=O)(=O)O{-}.[Na]{+})cccc9c7S(=O)(=O)O{-}.[Na]{+})c8O)nc(Cl)n6)cc5S(=O)(=O)O{-}.[Na]{+})c(S(=O)(=O)O{-}.[Na]{+})c4)nc(Cl)n3)cc2cc(S(=O)(=O)O{-}.[Na]{+})c1/N=N/c1ccc2c(S(=O)(=O)O{-}.[Na]{+})cccc2c1S(=O)(=O)O{-}.[Na]{+} - Oxygen conditions:
- not specified
- Inoculum or test system:
- other: Microorganisms
- Duration of test (contact time):
- 28 d
- Parameter followed for biodegradation estimation:
- other: BOD
- Key result
- Parameter:
- other: % degradability BOD
- Value:
- 0.84
- Sampling time:
- 28 d
- Remarks on result:
- other: other details not available
- Details on results:
- Percent biodegradation of the test chemical 1,5-Naphthalenedisulfonic acid, 2,2'-[(2,2'-disulfo[1,1'-biphenyl]-4,4'-diyl)bis[imino (6-chloro-1,3,5-triazine-4,2-diyl)imino (1-hydroxy-3-sulfo-6,2-naphthalenediyl)azo]]bis-, octasodium salt was estimated to be 0.84 % by considering BOD as parameter and Microorganism as inoculum in 28 days.
- Validity criteria fulfilled:
- not specified
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- Percent biodegradation of the test chemical 1,5-Naphthalenedisulfonic acid, 2,2'-[(2,2'-disulfo[1,1'-biphenyl]-4,4'-diyl)bis[imino (6-chloro-1,3,5-triazine-4,2-diyl)imino (1-hydroxy-3-sulfo-6,2-naphthalenediyl)azo]]bis-, octasodium salt was estimated to be 0.84 % by considering BOD as parameter and Microorganism as inoculum in 28 days. On the basis of percent degradability value it can be concluded that test chemical 1,5-Naphthalenedisulfonic acid, 2,2'-[(2,2'-disulfo[1,1'-biphenyl]-4,4'-diyl)bis[imino (6-chloro-1,3,5-triazine-4,2-diyl)imino (1-hydroxy-3-sulfo-6,2-naphthalenediyl)azo]]bis-, octasodium salt is not readily biodegradable.
- Executive summary:
Biodegradability of test chemical 1,5-Naphthalenedisulfonic acid, 2,2'-[(2,2'-disulfo[1,1'-biphenyl]-4,4'-diyl)bis[imino (6-chloro-1,3,5-triazine-4,2-diyl)imino (1-hydroxy-3-sulfo-6,2-naphthalenediyl)azo]]bis-, octasodium salt (CAS no. 68110-30-5) was estimated by using OECD QSAR tool box v3.3 by considering ten closest read across chemical log Kow as primary descriptor. Percent biodegradation of the test chemical 1,5-Naphthalenedisulfonic acid, 2,2'-[(2,2'-disulfo[1,1'-biphenyl]-4,4'-diyl)bis[imino (6-chloro-1,3,5-triazine-4,2-diyl)imino (1-hydroxy-3-sulfo-6,2-naphthalenediyl)azo]]bis-, octasodium salt was estimated to be 0.84 % by considering BOD as parameter and Microorganism as inoculum in 28 days. On the basis of percent degradability value it can be concluded that test chemical 1,5-Naphthalenedisulfonic acid, 2,2'-[(2,2'-disulfo[1,1'-biphenyl]-4,4'-diyl)bis[imino (6-chloro-1,3,5-triazine-4,2-diyl)imino (1-hydroxy-3-sulfo-6,2-naphthalenediyl)azo]]bis-, octasodium salt is not readily biodegradable.
Reference
The
prediction was based on dataset comprised from the following
descriptors: BOD
Estimation method: Takes average value from the 10 nearest neighbours
Domain logical expression:Result: In Domain
(((((((((((("a"
or "b" or "c" or "d" )
and ("e"
and (
not "f")
)
)
and "g" )
and "h" )
and "i" )
and ("j"
and (
not "k")
)
)
and ("l"
and (
not "m")
)
)
and ("n"
and (
not "o")
)
)
and ("p"
and (
not "q")
)
)
and ("r"
and (
not "s")
)
)
and ("t"
and (
not "u")
)
)
and ("v"
and "w" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as Anion OR Aromatic compound OR
Azo compound OR Cation OR Halogen derivative OR Hydroxy compound OR
Phenol OR Sulfonic acid derivative by Organic functional groups, Norbert
Haider (checkmol) ONLY
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as Alcohol, olefinic attach [-OH]
OR Aliphatic Nitrogen, one aromatic attach [-N] OR Aliphatic Nitrogen,
two aromatic attach [-N-] OR Amino Triazine/Pyrazine/Pyrimidine OR
Aromatic Carbon [C] OR Aromatic Nitrogen OR Azo [-N=N-] OR Chlorine,
aromatic attach [-Cl] OR Chlorine, olefinic attach [-Cl] OR Hydroxy,
aromatic attach [-OH] OR Miscellaneous sulfide (=S) or oxide (=O) OR
Nitrogen, two or tree olefinic attach [>N-] OR Olefinic carbon [=CH- or
=C<] OR Oxygen, one aromatic attach [-O-] OR Suflur {v+4} or {v+6} OR
Sulfonate, aromatic attach [-SO2-O] OR Sym-Triazine ring by Organic
functional groups (US EPA) ONLY
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as Aromatic amine OR Aromatic
heterocyclic halide OR Aryl OR Aryl halide OR Azo OR Biphenyl OR Fused
carbocyclic aromatic OR Overlapping groups OR Phenol OR Sulfonic acid by
Organic Functional groups (nested) ONLY
Domain
logical expression index: "d"
Referential
boundary: The
target chemical should be classified as Aromatic amine OR Aromatic
heterocyclic halide OR Aryl OR Aryl halide OR Azo OR Biphenyl OR Fused
carbocyclic aromatic OR Naphtalene OR Phenol OR Sulfonic acid OR
Triazine by Organic Functional groups ONLY
Domain
logical expression index: "e"
Referential
boundary: The
target chemical should be classified as No alert found by DNA binding by
OASIS v.1.3
Domain
logical expression index: "f"
Referential
boundary: The
target chemical should be classified as AN2 OR AN2 >> Michael-type
addition, quinoid structures OR AN2 >> Michael-type addition, quinoid
structures >> Quinoneimines OR AN2 >> Michael-type addition, quinoid
structures >> Quinones OR AN2 >> Nucleophilic addition to alpha,
beta-unsaturated carbonyl compounds OR AN2 >> Nucleophilic addition to
alpha, beta-unsaturated carbonyl compounds >> alpha, beta-Unsaturated
Aldehydes OR AN2 >> Schiff base formation OR AN2 >> Schiff base
formation >> alpha, beta-Unsaturated Aldehydes OR AN2 >> Schiff base
formation >> Polarized Haloalkene Derivatives OR AN2 >> Thioacylation
via nucleophilic addition after cysteine-mediated thioketene formation
OR AN2 >> Thioacylation via nucleophilic addition after
cysteine-mediated thioketene formation >> Haloalkenes with
Electron-Withdrawing Groups OR AN2 >> Thioacylation via nucleophilic
addition after cysteine-mediated thioketene formation >> Polarized
Haloalkene Derivatives OR Non-covalent interaction OR Non-covalent
interaction >> DNA intercalation OR Non-covalent interaction >> DNA
intercalation >> Fused-Ring Primary Aromatic Amines OR Non-covalent
interaction >> DNA intercalation >> Quinones OR Radical OR Radical >>
Generation of reactive oxygen species OR Radical >> Generation of
reactive oxygen species >> Thiols OR Radical >> Radical mechanism via
ROS formation (indirect) OR Radical >> Radical mechanism via ROS
formation (indirect) >> Fused-Ring Primary Aromatic Amines OR Radical >>
Radical mechanism via ROS formation (indirect) >> p-Aminobiphenyl
Analogs OR Radical >> Radical mechanism via ROS formation (indirect) >>
Quinones OR Radical >> Radical mechanism via ROS formation (indirect) >>
Single-Ring Substituted Primary Aromatic Amines OR Radical >> ROS
formation after GSH depletion (indirect) OR Radical >> ROS formation
after GSH depletion (indirect) >> Quinoneimines OR SN1 OR SN1 >>
Alkylation after metabolically formed carbenium ion species OR SN1 >>
Alkylation after metabolically formed carbenium ion species >>
Polycyclic Aromatic Hydrocarbon Derivatives OR SN1 >> Nucleophilic
attack after carbenium ion formation OR SN1 >> Nucleophilic attack after
carbenium ion formation >> N-Nitroso Compounds OR SN1 >> Nucleophilic
attack after metabolic nitrenium ion formation OR SN1 >> Nucleophilic
attack after metabolic nitrenium ion formation >> Fused-Ring Primary
Aromatic Amines OR SN1 >> Nucleophilic attack after metabolic nitrenium
ion formation >> p-Aminobiphenyl Analogs OR SN1 >> Nucleophilic attack
after metabolic nitrenium ion formation >> Single-Ring Substituted
Primary Aromatic Amines OR SN1 >> Nucleophilic attack after nitrenium
and/or carbenium ion formation OR SN1 >> Nucleophilic attack after
nitrenium and/or carbenium ion formation >> N-Nitroso Compounds OR SN2
OR SN2 >> Alkylation, direct acting epoxides and related OR SN2 >>
Alkylation, direct acting epoxides and related >> Epoxides and
Aziridines OR SN2 >> Alkylation, direct acting epoxides and related
after P450-mediated metabolic activation OR SN2 >> Alkylation, direct
acting epoxides and related after P450-mediated metabolic activation >>
Haloalkenes with Electron-Withdrawing Groups OR SN2 >> Alkylation,
direct acting epoxides and related after P450-mediated metabolic
activation >> Polycyclic Aromatic Hydrocarbon Derivatives OR SN2 >>
Direct acting epoxides formed after metabolic activation OR SN2 >>
Direct acting epoxides formed after metabolic activation >> Quinoline
Derivatives OR SN2 >> SN2 at an activated carbon atom OR SN2 >> SN2 at
an activated carbon atom >> Quinoline Derivatives OR SN2 >> SN2 at sp3
and activated sp2 carbon atom OR SN2 >> SN2 at sp3 and activated sp2
carbon atom >> Polarized Haloalkene Derivatives by DNA binding by OASIS
v.1.3
Domain
logical expression index: "g"
Referential
boundary: The
target chemical should be classified as Not calculated by Biodeg BioHC
half-life (Biowin) ONLY
Domain
logical expression index: "h"
Referential
boundary: The
target chemical should be classified as Not calculated by Biodeg
ultimate (Biowin 3) ONLY
Domain
logical expression index: "i"
Referential
boundary: The
target chemical should be classified as Not calculated by Biodeg
ultimate (Biowin 3) ONLY
Domain
logical expression index: "j"
Referential
boundary: The
target chemical should be classified as Non binder, MW>500 by Estrogen
Receptor Binding
Domain
logical expression index: "k"
Referential
boundary: The
target chemical should be classified as Non binder, impaired OH or NH2
group by Estrogen Receptor Binding
Domain
logical expression index: "l"
Referential
boundary: The
target chemical should be classified as Non binder, MW>500 by Estrogen
Receptor Binding
Domain
logical expression index: "m"
Referential
boundary: The
target chemical should be classified as Moderate binder, NH2 group OR
Moderate binder, OH grooup by Estrogen Receptor Binding
Domain
logical expression index: "n"
Referential
boundary: The
target chemical should be classified as Non binder, MW>500 by Estrogen
Receptor Binding
Domain
logical expression index: "o"
Referential
boundary: The
target chemical should be classified as Non binder, without OH or NH2
group by Estrogen Receptor Binding
Domain
logical expression index: "p"
Referential
boundary: The
target chemical should be classified as Non binder, MW>500 by Estrogen
Receptor Binding
Domain
logical expression index: "q"
Referential
boundary: The
target chemical should be classified as Weak binder, NH2 group by
Estrogen Receptor Binding
Domain
logical expression index: "r"
Referential
boundary: The
target chemical should be classified as Non binder, MW>500 by Estrogen
Receptor Binding
Domain
logical expression index: "s"
Referential
boundary: The
target chemical should be classified as Weak binder, OH group by
Estrogen Receptor Binding
Domain
logical expression index: "t"
Referential
boundary: The
target chemical should be classified as Non binder, MW>500 by Estrogen
Receptor Binding
Domain
logical expression index: "u"
Referential
boundary: The
target chemical should be classified as Very strong binder, OH group by
Estrogen Receptor Binding
Domain
logical expression index: "v"
Parametric
boundary:The
target chemical should have a value of log BCF max which is >= 0.959
log(L/kg wet)
Domain
logical expression index: "w"
Parametric
boundary:The
target chemical should have a value of log BCF max which is <= 3.08
log(L/kg wet)
Description of key information
Biodegradability of test chemical 1,5-Naphthalenedisulfonic acid, 2,2'-[(2,2'-disulfo[1,1'-biphenyl]-4,4'-diyl)bis[imino (6-chloro-1,3,5-triazine-4,2-diyl)imino (1-hydroxy-3-sulfo-6,2-naphthalenediyl)azo]]bis-, octasodium salt (CAS no. 68110-30-5) was estimated by using OECD QSAR tool box v3.3 by considering ten closest read across chemical log Kow as primary descriptor. Percent biodegradation of the test chemical 1,5-Naphthalenedisulfonic acid, 2,2'-[(2,2'-disulfo[1,1'-biphenyl]-4,4'-diyl)bis[imino (6-chloro-1,3,5-triazine-4,2-diyl)imino (1-hydroxy-3-sulfo-6,2-naphthalenediyl)azo]]bis-, octasodium salt was estimated to be 0.84 % by considering BOD as parameter and Microorganism as inoculum in 28 days. On the basis of percent degradability value it can be concluded that test chemical 1,5-Naphthalenedisulfonic acid, 2,2'-[(2,2'-disulfo[1,1'-biphenyl]-4,4'-diyl)bis[imino (6-chloro-1,3,5-triazine-4,2-diyl)imino (1-hydroxy-3-sulfo-6,2-naphthalenediyl)azo]]bis-, octasodium salt is not readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
Predicted data study for target chemical 1,5-Naphthalenedisulfonic acid, 2,2'-[(2,2'-disulfo[1,1'-biphenyl]-4,4'-diyl)bis[imino (6-chloro-1,3,5-triazine-4,2-diyl)imino (1-hydroxy-3-sulfo-6,2-naphthalenediyl)azo]]bis-, octasodium salt (CAS no. 68110-30-5) and experimental studies for its structurally similar read across chemicals have been conducted and their results are summarized below for biodegradation in water endpoint.
Another study was experimental study done from Chemosphere journal Vo1.15 (1986) for structurally similar read across chemical Disodium 4,4'-bis(2-hydroxynaphthalen-1-ylazo)biphenyl-2,6'-disulphonate (CAS no.10169 -02 -5) in this study the aerobic biodegradation experiment was performed for read across chemical Disodium 4,4'-bis(2-hydroxynaphthalen-1-ylazo)biphenyl-2,6'-disulphonate using activated sludge at concentration 0.5 g/L dry material as inoculums and initial concentration of chemical taken was 100mg/L for 42 days. By considering DOC removal parameter read across chemical showed 17% degradation in 42 days. The read across chemical Disodium 4,4'-bis(2-hydroxynaphthalen-1-ylazo)biphenyl-2,6'-disulphonate belongs to D category according to table 1 and 2 as its limit value falls in that range. This percentage value is very less So it is concluded that Disodium 4,4'-bis(2-hydroxynaphthalen-1-ylazo)biphenyl-2,6'-disulphonate (CAS no. 10169 -02 -5) is not readily biodegradable.
Next study was also experimental study done from same source as mentioned in above experimental study in this study the aerobic biodegradation experiment was performed for read across chemical tetrasodium;3-[[4-[[4-[(2E)-2-(6-amino-1-oxo-3-sulfonatonaphthalen-2-ylidene)hydrazinyl]-6-sulfonatonaphthalen-1-yl]diazenyl]naphthalen-1-yl]diazenyl]naphthalene-1,5-disulfonate CAS no. 4399 -55 -7) using activated sludge at concentration 0.5 g/L dry material as inoculums and initial concentration of chemical taken was 100 mg/L for 42 days. By considering DOC removal parameter read across chemical showed -27 % degradation in 42 days. This percentage value is very less So it is concluded that read across chemical tetrasodium; 3-[[4-[[4-[(2E)-2-(6-amino-1-oxo-3-sulfonatonaphthalen-2-ylidene)hydrazinyl]-6-sulfonatonaphthalen-1-yl]diazenyl]naphthalen-1-yl]diazenyl]naphthalene-1,5-disulfonate is not readily biodegradable.
On the basis of results of all the studies mentioned above for target chemical 1,5-Naphthalenedisulfonic acid, 2,2'-[(2,2'-disulfo[1,1'-biphenyl]-4,4'-diyl)bis[imino (6-chloro-1,3,5-triazine-4,2-diyl)imino (1-hydroxy-3-sulfo-6,2-naphthalenediyl)azo]]bis-, octasodium salt (CAS no. 68110-30-5) and for its structurally similar read across chemicals it can be concluded that test chemical is not readily biodegradable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.