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EC number: 413-060-1 | CAS number: 19186-97-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP and appropriate guidelines
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-3 (Acute inhalation toxicity)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- not relevant
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 413-060-1
- EC Name:
- -
- Cas Number:
- 19186-97-1
- Molecular formula:
- C15 H24 O4 P Br9
- IUPAC Name:
- tris[3-bromo-2,2-bis(bromomethyl)propyl] phosphate
- Reference substance name:
- 4130601
- IUPAC Name:
- 4130601
- Details on test material:
- Identity: PB-370
Reference No.: E8200-58
Storage: Room temperature
Purity: 100%
Physical description: Fine white powder
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Young adult Sprague-Dawley (Ctl:CDBR VAF Plus) received from Charles River Labs. Kingston NY.
Diet: Fresh tap water and Purina Labortory Rodent Chow 5001 were available ab libitum.
Animals were acclimated for a minimum of 5 days prior to study start.
Temperature: 63-77 Deg F
RH: 37-71%
Animal identification was established by the use of ear tags and cage cards.
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Remarks:
- see attached document on exposure system and monitoring
- Vehicle:
- air
- Remarks:
- Breathing grade compressed
- Details on inhalation exposure:
- Whole body exposure, BGI Wright Dust Feeder II
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 12.1 mg/L (nominal)
- No. of animals per sex per dose:
- 5 male and 5 female
- Control animals:
- no
- Details on study design:
- See attached document on methods
- Statistics:
- see attached document on methods
Results and discussion
- Preliminary study:
- n/a
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 1.81 mg/L air
- Exp. duration:
- 4 h
- Mortality:
- Male: 1.8 mg/L; Number of animals: 5; Number of deaths: 0
Female: 1.8 mg/L; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: Signs of toxicity related to dose levels: There were no significant clinical signs noted during or after the exposure to the test material. A few non-significant clinical signs were noted during the exposure; upon removal from the chamber and at one h
- Body weight:
- All animals gained weight on day 14
- Gross pathology:
- Effects on organs:
No treatment-related organ effects. - Other findings:
- see attached document on results
Any other information on results incl. tables
see attached document on tables and figures
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test material caused no mortality when administrated for 4 hours to Sprague Dawley rats at a mean gravimetric analytically determined chamber concentration of 1.81 mg/l
- Executive summary:
A group of five male and five female Sprague-Dawley rats was exposed to a respirable particulate
atmosphere of PB-370 for 4 hours at a mean, maximum-attainable concentration of 1.81 mg/l in a
dynamically-operated, whole-body inhalation exposure chamber. Gravimetric airborne test material
samples were taken at approximately 30 minute intervals during the exposure. Particle size
samples were taken twice during the exposure. Observations for toxicity and mortality were .
performed frequently during the exposure, upon removal of the rats from the chamber, at one hour
post-exposure and twice daily thereafter for 13 days; on day 14 observations were performed once.
Individual body weights were recorded immediately prior to exposure on day 0 and on days 1, 2, 4, 7
add 14. On day 14, all animals were sacrificed and gross necropsy examinations were performed.
There were no significant clinical signs noted during or after the exposure to the test material. A few
non-significant clinical signs were noted during the exposure, upon removal from the chamber and at
one hour post-exposure including abdominogenital staining, chromorhinorrhea, dust on fur,
lacrimation and squinting eyes. All animals recovered by study day 1 and remained healthy through
study termination.
All animals gained weight by termination on day 14. There were no gross internal lesions noted in
any animal at necropsy.
Under the conditions of this study, the test material caused no mortality at a mean maximum
attainable concentration of 1.81 mg/l.
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