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EC number: 205-581-6 | CAS number: 143-06-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1965
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 965
- Report date:
- 1965
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test: Acute Oral Gavage (pre-guideline pre-GLP study)
- Short description of test conditions: The test material was administered by intragastric intubation to five group of ten young adult rat at dose of 5000, 3400, 3020, 2630, 2250 mk/kg. Surivors were sacrificed 14 days later. The oral LD50 was calculated.
- Parameters analysed / observed: Cliinical signs, gross pathologic changes - GLP compliance:
- no
- Remarks:
- pre-GLP study
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- (6-aminohexyl)carbamic acid
- EC Number:
- 205-581-6
- EC Name:
- (6-aminohexyl)carbamic acid
- Cas Number:
- 143-06-6
- Molecular formula:
- C7H16N2O2
- IUPAC Name:
- (6-aminohexyl)carbamic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- CD-1
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Species: Charles River CD
- Sex: males
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- Vehicle detalies not specified
- Doses:
- 5000, 3400, 3020, 2630, 2250 mg/kg
- No. of animals per sex per dose:
- 5 groups - 10 animals each group
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Examinations performed: clinical signs, Gross pathologic changes - Statistics:
- Oral LD50 calculated from mortality data using the method of Litchfield and Wilcoxon (1949).
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 2 875 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 2 614 - <= 3 162
- Mortality:
- 2250 mg/Kg - 1/10
2630 mg/Kg - 2/10
3020 mg/Kg - 7/10
3400 mg/Kg - 8/10
5000 mg/Kg - 10/10 - Clinical signs:
- other: Pallor, apparent discomfort, belly-crawling after dosing, weight loss for 1-2 days, diarrhoea, stained ventral area and hematuria at two higher doses.
- Gross pathology:
- Animals that died (5): dark bone marrow, hyperemic thymus, stomach and intestine distended with fluid, intestine and glandular mucosa of stomach hemorrhagic
Animal that survived (8): thickened stomach mucosa and, at higher levels, adhesions of liver to stomach
Any other information on results incl. tables
Mortality observed in the study
Dose mg/kg |
Solution % |
Mortality Ratio |
5000 |
50 |
10/10 |
3400 |
20 |
8/10 |
3020 |
30 |
7/10 |
2630 |
30 |
2/10 |
2250 |
40 |
1/10 |
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified according to the CLP Regulation
- Conclusions:
- Under the conditions of this study, the acute oral LD50 of the test material in male rats was determined to be 2875 mg/Kg (95% C.I: 2614 - 3162 mg/Kg).
- Executive summary:
In a key pre-guideline acute oral toxicity study, the test material was administered via intragastric intubation to Charles River CD rats (10 males/dose) at doses of 2250, 2630, 3020, 3400, or 5000 mg/Kg. Animals were observed for clinical signs and gross pathologic changes with surviving animals sacrificed 14 days post exposure.
Mortality was observed at each dose level as follows: 2250 mg/Kg (1/10); 2630 mg/Kg (2/10); 3020 mg/Kg (7/10); 3400 mg/Kg (8/10); 5000 mg/Kg (10/10). Clinical signs observed through the study period included pallor, discomfort, belly-crawling after dosing, weight loss for 1-2 days, diarrhoea, stained ventral area as well as hematuria observed at the two higher doses.
Dark bone marrow, hyperemic thymus, stomach and intestine distended with fluid, and hemorrhagic intestine and glandular mucosa of the stomach were observed in animals that died (5). In animals that survived (8), thickened stomach mucosa and, at higher dose levels, adhesion of the liver to the stomach were observed.
Based on mortality and clinical signs of toxicity as well as gross pathology observed in the study, the acute oral LD50 (calculated using the Litchfield and Wilcoxon method (1949)) was determined to be 2875 mg/Kg (95% C.I: 2614 – 3162 mg/Kg).
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