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EC number: 208-047-0 | CAS number: 506-61-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Remarks:
- Predicted based on mixture toxicity assessment, acceptable with restrictions
- Principles of method if other than guideline:
- The acute toxicity of silver cyanide compounds is predicted based on information about the acute toxicity of the individual components (i.e.silver, and cyanide). Information on the toxicity of the different components is combined with predictions of the speciation of the precious metal cyanide compound in typical ecotoxicity test media.
All chemical speciation calculations were performed using VisualMINTEQ (Version 3.0). Measured Daphnia test results for potassium dicyanoargentate have been used to validate the predictions from the mixture toxicity assessment. Comparison of the measured and modelled values indicates that the modelling approach is reliable for silver cyanide substances. - GLP compliance:
- no
- Test organisms (species):
- Pimephales promelas
- Details on test organisms:
- EC50 values were predicted for Oncorhynchus mykiss and Pimephales promelas based on acute toxicity data for silver and cyanide, as these species are the most sensitive to both silver and cyanide. The lowest predicted EC50 value, for Pimephales promelas, is used to fill the acute toxicity to fish endpoint for potassium dicyanoargentate.
- Total exposure duration:
- 96 h
- Details on test conditions:
- Predictions for potassium dicyanoargentate are based on the most sensitive acute toxicity data for silver and cyanide.
For cyanide, the most sensitive species tested was Oncorhynchus mykiss, with acute LC50 values ranging from 27 to 97 µg (CN-) l-1. The geometric mean of acute LC50 values for Oncorhynchus mykiss is 57 µg (CN-) l-1. Data are also available for the toxicity of cyanide to Pimephales promelas, which was slightly less sensitive then Oncorhynchus mykiss. Thirty-five tests on this species were reported, with LC50 values ranging from 79 to 339 µg (CN-) l-1, and a geometric mean of 137 µg (CN-) l-1.
For silver, the most sensitive fish species in acute toxicity tests was Pimephales promelas, with a 96 hour EC50 value of 1.2 µg l-1 dissolved silver. Data are also available for the toxicity of silver to Oncorhynchus mykiss, which was found to be slightly less sensitive with an LC50 value of 3.3 µg l-1 dissolved silver. Details of the water chemistry of these tests were not available to enable calculation of the test endpoints on a free Ag+ basis. In the absence of this information the fraction of dissolved silver which was present as free Ag+ in the critical Daphnia test (0.44) was also assumed for these tests.
Mixture toxicity has been assessed according to the “Concentration Addition” method. This method considers the relative risk, or pressure, exerted by each potentially toxic component on the basis of the risk characterisation ratio, and the risk characterisation ratios for each of the individual components are added together to determine the overall risk
For potassium dicyanoargentate silver is likely to provide the dominant contribution to the overall toxicity, but cyanide may also contribute to a lesser extent. - Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 3.3 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: The LC50 value was predicted based on acute toxicity data for silver and cyanide and speciation predictions for potassium dicyanoargentate
- Details on results:
- The LC50 for potassium dicyanoargentate was predicted based on acute toxicity data for silver and cyanide and speciation predictions for potassium dicyanoargentate. The results of the mixture toxicity assessment were validated based on measured results for Daphnia. The modelled and measured EC50 values for toxicity of potassium dicyanoargentate to Daphnia are in excellent agreement (0.0257 mg/L modelled, 0.022 mg/L measured) and therefore the predictions for acute toxicity to fish are considered to be reliable.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The LC50 for potassium dicyanoargentate is predicted to be 3.3 mg/L. Acute toxicity to fish is predicted using a mixture toxicity approach, based on acute ecotoxicity data for silver and cyanide and speciation predictions for potassium dicyanoargentate.
- Executive summary:
In order to minimise the need for animal testing a calculation approach has been used in order to determine the acute toxicity of potassium dicyanoargentate. As a large body of ecotoxicity data is already available for silver and cyanide, the toxicity of potassium dicyanorgentate is predicted based on the measured values for silver and cyanide and the speciation of the precious metal cyanide substance in the test solution.
The results of the mixture toxicity assessment were validated using measured results for Daphnia. The modelled and measured EC50 values for toxicity of potassium dicyanoargentate to Daphnia are in excellent agreement (0.0257 mg/L modelled, 0.022 mg/L measured) and therefore the predictions for acute toxicity to fish are considered to be reliable.
Reference
Description of key information
The LC50 for potassium dicyanoargentate is predicted to be 3.3 mg/L. Acute toxicity to fish is predicted using a mixture toxicity approach, based on acute ecotoxicity data for silver and cyanide and speciation predictions for potassium dicyanoargentate.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 3.3 mg/L
Additional information
In order to minimise the need for animal testing a calculation approach has been used in order to determine the acute toxicity of potassium dicyanoargentate. As a large body of ecotoxicity data is already available for silver and cyanide, the toxicity of potassium dicyanoargentate is predicted based on the measured values for silver and cyanide and the speciation of the precious metal cyanide substance in the test solution.
The results of the mixture toxicity assessment were validated using measured results for Daphnia. The modelled and measured EC50 values for toxicity of potassium dicyanoargentate to Daphnia are in excellent agreement (0.0257 mg/L modelled, 0.022 mg/L measured) and therefore the predictions for acute toxicity to fish are considered to be reliable.
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