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Diss Factsheets
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EC number: 204-429-6 | CAS number: 120-83-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1985
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The SIDS document contains the information gathered and an initial assessment performed under the framework of the OECD HPV Chemicals Programme. The information is provided as an indication of the current state of knowledge of this substance based on the Screening Information Data Set (SIDS), but does not presume to be comprehensive. The SIDS document for 2,4-Dichlorophenol has been peer reviewed by the French government and was performed by the National Institute on Environmental and Industrial Risk (INERIS) by request from the Ministry of Environment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 985
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- Principles of method if other than guideline:
- No additional details presented
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,4-dichlorophenol
- EC Number:
- 204-429-6
- EC Name:
- 2,4-dichlorophenol
- Cas Number:
- 120-83-2
- Molecular formula:
- C6H4Cl2O
- IUPAC Name:
- 2,4-dichlorophenol
- Details on test material:
- The purity of the substance (purchased from Aldrich) is reported as 99%
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CD-1
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Doses were administered by gavage to 6 week-old male and female CD-1 ICR mice (8 animals/sex/group; 5 dose levels, 1 animal/cage). Temperature was maintained at : 22°+/-2°C, Humidity at: 40-60% and the Light cycle was : 12h/d.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- 10 ml/kg were administered by gavage to 6 week-old male and female CD-1 ICR mice (8 animals/sex/group; 5 dose levels, 1 animal/cage).
- Doses:
- 5 dose levels were administered
- No. of animals per sex per dose:
- Eight
- Control animals:
- not specified
- Details on study design:
- LD50 is calculated by probit analysis and Litchfield-Wilcoxon test.
Results and discussion
- Preliminary study:
- No information on a preliminary study is reported.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 1 276 - < 1 352 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All deaths occurred within 6-24 hours after dosing.
- Clinical signs:
- other: All animals displayed signs evocating CNS disorders within 10-15 min after dosing: ataxia, loss of righting reflex, slight tremors, salivation, laboured breathing and depression.
- Gross pathology:
- At necropsy, no gross abnormalities were noted in dead animals nor in survivors after a 2-week observation period.
- Other findings:
- None
Any other information on results incl. tables
No additional information presented
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 was determined (in mice [male/female]) in a study similar to OECD guideline 401. The results indicate the LD50 to range between 1276 and1352 mg/kg bw.
- Executive summary:
An LD50 study was conducted in male and female mice using a method similar to OECD guideline 401.
The substance purity is reported as 99% (as procured from Aldrich) at the beginning of the study.
In the course of the study clinical signs noted included : CNS disorders within 10-15 min after dosing: ataxia, loss of righting reflex, slight tremors, salivation, laboured breathing and depression.
The results indicate the LD50 to range between 1276 and 1352 mg/kg bw.
This study is assigned a reliablility of 1, valid without restriction in the SIDS document
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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