Registration Dossier
Registration Dossier
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EC number: 203-247-4 | CAS number: 104-88-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4-chlorobenzaldehyde
- EC Number:
- 203-247-4
- EC Name:
- 4-chlorobenzaldehyde
- Cas Number:
- 104-88-1
- Molecular formula:
- C7H5ClO
- IUPAC Name:
- 4-chlorobenzaldehyde
- Details on test material:
- - purity: 99 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: obtained from breeder Winkelmann
- Weight at study initiation: 160 - 180 g
- Housing: 5 animals per caqge, SPF
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Lutrol
- Doses:
- 600, 700, 800, 900, 1000 or 1200 mg/kg bw
- No. of animals per sex per dose:
- - 10 male rats per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- LD50 was calculated according to Fink an dHund, Arzneim.-Forsch. 15, 624 (1965).
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 840 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 780 - 910
- Mortality:
- see "any other information on results incl. tables"
- Clinical signs:
- other: All animals receiving more than 600 mg/kg bw showed clinical symptoms. The symptoms included poor general state, diarrhoea, bloody nose, sedation or epistaxis.
- Gross pathology:
- no data
- Other findings:
- see table below
Any other information on results incl. tables
Mortality:
Dose [mg/kg bw] |
Time of death |
dead animals |
animals with symptoms |
treated animals |
|
|
|
|
|
600 |
- |
0 |
0 |
10 |
700 |
3 h |
3 |
10 |
10 |
800 |
2 d |
3 |
10 |
10 |
900 |
2 d |
5 |
10 |
10 |
1000 |
2 d |
9 |
10 |
10 |
1200 |
3 h |
10 |
10 |
10 |
Applicant's summary and conclusion
- Executive summary:
In a acute oral toxicity study (Bayer AG, Department of Toxicology, 1979), groups of young adult Wistar rats (10 males per group) were given a single oral dose of p-Chlorobenzaldehyde (99 % a.i.) in Lutrol at doses of 600, 700, 800, 900, 1000 or 1200 mg/kg bw and observed for 14 days.
The oral LD50 value was established to be 840 mg/kg bw.
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