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EC number: 240-979-3 | CAS number: 16921-30-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 April 1995 - 8 November 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study carried out according to GLP and OECD guideline 401 (current at 1995).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Dipotassium hexachloroplatinate
- EC Number:
- 240-979-3
- EC Name:
- Dipotassium hexachloroplatinate
- Cas Number:
- 16921-30-5
- Molecular formula:
- Cl6Pt.2K
- IUPAC Name:
- dipotassium hexachloroplatinate(2-)
- Details on test material:
- - Name of test material (as cited in study report): Potassiumhexachloroplatinate(IV)
- Substance type:
- Physical state: Powder
- Analytical purity: >99.9%
- Impurities (identity and concentrations):
- Composition of test material, percentage of components:
- Isomers composition:
- Purity test date:
- Lot/batch No.: 8833 / June 23, 1994
- Expiration date of the lot/batch:
- Stability under test conditions: According to sponsor, the test substance was stable throughout the experimental period
- Storage condition of test material: Closed container in refrigerator
- Other:
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Wistar-Unilever (HsdCpb:Wu)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan-Winkelmann GmbH, D-33176 Borchen
- Age at study initiation: Males 8-9 weeks; Females 9-10 weeks
- Weight at study initiation: Males 166-218 g; Females 140-170 g
- Fasting period before study: Approx. 16 hours before treatment
- Housing: Macrolon cages, type II
- Diet (e.g. ad libitum): Standard diet ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least 5 days before administration
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21-22
- Humidity (%): 43-64
- Air changes (per hr): not stated
- Photoperiod (hrs dark / hrs light): 12 / 12
IN-LIFE DATES: From: To:
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- 1%
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 21.5 - 100 mg/ml (males and females)
- Amount of vehicle (if gavage): 4.64 ml/kg bw
- Justification for choice of vehicle: not stated
- Lot/batch no. (if required): E 114 30100
- Purity: not stated
MAXIMUM DOSE VOLUME APPLIED: 4.64 ml/kg bw
DOSAGE PREPARATION (if unusual): Test substance was suspended in the vehicle immediately before dosing using a homogenizer - Doses:
- 100, 215 or 464 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Continously for first 4 - 6 hours, and then once daily. Body weights recorded at the beginning and also 7 and 14 days after administration, or after death of the animals on days 2 - 14.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, histopathology (kidneys) - Statistics:
- Probit analysis
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 195 mg/kg bw
- 95% CL:
- >= 142 - <= 268
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 184 mg/kg bw
- 95% CL:
- >= 85.1 - <= 357
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 212 mg/kg bw
- 95% CL:
- >= 105 - <= 423
- Mortality:
- 10/10 at 464 mg/kg bw dose
4/5 males at 215 mg/kg bw dose
3/5 females at 215 mg/kg bw dose
Time of death: 5/sex between 6-24 h post-dose of 464 mg/kg bw. 215 mg/kg bw dose: 1, 2 and 1 males died on days 2, 3 and 5, respectively; females, 1,1 and 1 died 6-24 h and days 2 and 3, respectively. - Clinical signs:
- other: Onset of symptoms only reported as occurring 1.5 hr - 4 days after treatment. Deceased animals: 464 mg/kg bw: hypokinesia, diarrhoea, sunken sides, stilted, restrained and staggered gait, tremor, clonic convulsions, tonic convulsions of the hind legs, su
- Gross pathology:
- 464 mg/kg bw: males - glandular stomach reddened and/or hardened walls (5), yellow deposit in glandular mucosa (5), small intestine filled with fluid (3) lung beige discolouration (1).
Females - glandular stomach reddened and/or hardened walls (5), yellow deposit in glandular mucosa (5), Stomach (3) or small intestine (4) filled with fluid, non-collapsed lung (1).
215 mg/kg bw: males - glandular stomach reddened and/or hardened walls (4), small intestine (1), bladder (1) and thoracic cavity (2) filled with fluid, pale kidneys (2), stomach yellow content (1). Females - glandular stomach reddened and/or hardened walls (3), small intestine (2) and thoracic cavity (1) filled with fluid. - Other findings:
- Microscopic findings: 5/sex showed marked necrosis and degeneration of the proximal renal tubules at 464 mg/kg bw, and 3 males and 1 female at 215 mg/kg bw. Minimal to marked changes in proximal tubules in 1 male and 2 females at 215 mg/kg bw and 3/sex at 100 mg/kg bw.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral LD50 of potassium hexachloroplatinate was determined to be 195 mg/kg bw in rats.
- Executive summary:
The acute toxicity of potassium hexachloroplatinate was investigated in Sprague-Dawley rats, in an OECD Test Guideline 401 study, conducted according to GLP. Animals (5/sex/group) were administered the test substance (as a suspension in 1% carboxymethylcellulose) by oral gavage at doses of 100, 215 or 464 mg/kg bw, and observed for up to 14 days.
All animals died at the top dose, while 4 males and 3 females died at 215 mg/kg bw. Deaths occurred 1 to 5 days after administration. No mortality was observed in the low dose groups. Toxic effects included hypokinesia, stilted, staggered and restrained gait, tremor, diarrhoea, and sunken sides. Additionally, clonic and tonic convulsions and piloerection were detected. Individual animals showed loss of muscle tone and righting, pain and corneal reflexes, red crusted nose, or prolapse of penis. Microscopic examination of the kidneys revealed severe to very severe acute necrosis and degeneration of the proximal tubules at the highest two doses. The acute oral LD50 was determined (using probit analysis) to be 184 mg/kg bw in male rats (95% CI 85.1-357 mg/kg bw), 212 mg/kg bw in females (95% CI 105-423 mg/kg bw) and 195 mg/kg bw for both sexes combined (95% CI 142 -268 mg/kg bw).
Based on the results of this study, the test material should be classified for acute oral toxicity (category 3) according to EU CLP criteria (EC 1272/2008).
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