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EC number: 210-772-2 | CAS number: 623-12-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to microorganisms, other
- Remarks:
- Tetrahymena
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1994
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test: growth inhibition
- GLP compliance:
- no
- Specific details on test material used for the study:
- Each chemical (totally 20 chemicals tested) was purchased from either Aldrich Chemical Co., Milwaukee, WI, USA, or ICN Biomedicals, Inc.,
Costa Mesa, CA, USA, and each had a purity of 95% or greater. - Analytical monitoring:
- no
- Vehicle:
- yes
- Remarks:
- the final DMSO concentration was not in excess of 0.35 ml per flask, an amount that does not alter Tetrahymena population growth (Schultz and Cajina-Quezada 1982).
- Details on test solutions:
- Stock solutions were prepared in dimethylsulfoxide (DMSO) at concentrations of 5, 10, 25, or 50 g/L.
- Test organisms (species):
- Tetrahymena pyriformis
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 2 d
- Test temperature:
- 27 +- 1 °C
- pH:
- 7.35
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 250-ml Erlenmeyer flasks
- Fill volume: 50 ml of sterile medium.
- No. of vessels per concentration (replicates): 3
- Biomass loading rate: 2,500 cells/ml.
EFFECT PARAMETERS MEASURED:
population density measured spectrophotometrically at 540 nm
TEST CONCENTRATIONS
6--8 step concentration series.
Only replicates with control values in late log-growth-phase (absorbance from 0.6 to 0.9) were used in the analyses. - Reference substance (positive control):
- no
- Remarks:
- Totally 26 substances tested
- Key result
- Duration:
- 2 d
- Dose descriptor:
- IC50
- Effect conc.:
- 30.51 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Remarks on result:
- other: 95% CI: 21.70-38.04 mg/L
- Reported statistics and error estimates:
- Probit Analysis of Statistical Analysis System (SAS) software (SAS Institute Inc. 1989)
- Validity criteria fulfilled:
- yes
- Conclusions:
- In a test on toxicity on Tetrahymena pyriformis 50% of the growth were inhibited at 30.51 mg/L.
- Endpoint:
- toxicity to microorganisms, other
- Remarks:
- Tetrahymena
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1999
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- no guideline followed
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- Tetrahymena pyriformis
- Details on inoculum:
- strain GL-C
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 40 h
- Details on test conditions:
- TEST SYSTEM
- No. of vessels per concentration (replicates): 3
- No. of vessels per vehicle control (replicates): 2
EFFECT PARAMETERS MEASURED:
population density quantitated spectrophotometrically at 540 nm as its end point
TEST CONCENTRATIONS
Six to eight different concentrations of each test material with duplicate flasks with each concentration. Only replicates with control absorbency values of >0.6 but <0.75 were used in the analyses. - Reference substance (positive control):
- no
- Remarks:
- totally 200 substances tested
- Key result
- Duration:
- 40 h
- Dose descriptor:
- IC50
- Effect conc.:
- 4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Reported statistics and error estimates:
- Probit Analysis of Statistical Analysis System (SAS) software
- Validity criteria fulfilled:
- yes
- Conclusions:
- In a test on toxicity on Tetrahymena pyriformis 50% of the growth were inhibited at 4 mg/L.
Referenceopen allclose all
Toxicity value as stated in the publication: log(IGC50 -1) = 0.60
( IGC50: 50% growth inhibitory concentration)
Description of key information
In a test on toxicity on Tetrahymena pyriformis 50% of the growth were inhibited at 30.51 mg/L.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 30.51 mg/L
Additional information
In a further study an IGC50 value of 4 mg/L was determined.
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