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EC number: 202-462-0 | CAS number: 95-88-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August/September, 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Guideline:
- other: not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-chlororesorcinol
- EC Number:
- 202-462-0
- EC Name:
- 4-chlororesorcinol
- Cas Number:
- 95-88-5
- Molecular formula:
- C6H5ClO2
- IUPAC Name:
- 4-chlorobenzene-1,3-diol
- Test material form:
- other:
- Remarks:
- beige powder
- Details on test material:
- Molecular weight: 144.65
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CFY
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Rats, in the weight range 95 to 122g were starved overnight before treatment with 4-chlororeaorcinol.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: aqueous sodium sulphite (0. 05%) solution
- Details on oral exposure:
- 4·Chlororesorcinol was prepared as a 10% solution in aqueous sodium sulphite (0. 05%) and administered by oral intubation at a range of dosage volumes in the full scale test of 1.6 to 6.4 ml/kg bodyweight.
- Doses:
- 160, 250, 400, 640 mg/kg
- No. of animals per sex per dose:
- 4
- Control animals:
- yes
- Details on study design:
- Rats of the CFY strain, in the weight range 95 to 122g were starved overnight before treatment with 4-chlororeaorcinol.
4·Chlororesorcinol was prepared as a I0% solution in aqueous sodium sulphite (0. 05%) and administered by oral intubation at a range of dosage volumes in the full scale test of 1.6 to 6.4 ml/kg bodyweight. Rats treated with the vehicle alone (6. 4 ml/kg) served as controls.
During the observation period of 14 days, a record was kept of all mortalities and signs of toxicity. All rats that died were examined macroscopically in an attempt to identify the target organs, and those animals surviving terminally were similarly examined to detect possible residual damage.
From the mortality data the LD50 and its 95%o confidence limits were calculated by the method of Weil C. S. (1952), Biometrics, 8, 249.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 369 mg/kg bw
- Mortality:
- Death occurred from within one to two hours of treatment.
- Clinical signs:
- other: Signs of reaction to treatment, observed shortly after dosing, included lethargy, piloerection and decreased respiratory rate. These signs were accompanied by fine body tremors in rats treated at 160, 250 and 400 mg/kg, by ataxia in female rats at 160 and
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The acute median lethal oral dose (LD50) and its 95% confidence limits to rats of 4-chlororesorcinol were calculated to be:
369 (314 to 433) mg/kg bodyweight. - Executive summary:
The results of preliminary range finding tests indicated that the median lethal oral dose (LD50 ), was in the region of 250 to 640 mg/kg bodyweight. Dosing was then extended to larger groups of rats (five males and five females) in order to locate the median lethal dose more precisely. Signs of reaction to treatment, observed shortly after dosing, included lethargy, piloerection and decreased respiratory rate. These signs were accompanied by fine body tremors in rats treated at 160, 250 and 400 mg/kg, by ataxia in female rats at 160 and 400 mg/kg and all rats at 640 mg/kg and by loss of righting reflex and coarse body tremore: in rats at 640 mg/kg. Death occurred from within one to two hours of treatment. Autopsy revealed slight haemorrhage of the lungs, darkening of the liver, kidneys and spleen, and injection of mesenteric blood vessels. Recovery of survivors, as judged by external appearance and behaviour, was apparently complete within two days of treatment. This observation was substantiated by normal bodyweight gains compared with controls and normal autopsy findings.
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