Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-977-6 | CAS number: 130-15-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1993
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- 1,4-Naphthoquinone - BUA Report 211 (October 1998)
- Author:
- GDCh-Advisory Committee on Existing Chemicals (BUA)
- Year:
- 1 998
- Bibliographic source:
- S.Hirzel Verlag Stuttgart; Wissenschaftliche Verlags-Gesellschaft Stuttgart, 2000 , ISBN3-7776-1064-X
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- performed in 1981
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,4-naphthoquinone
- EC Number:
- 204-977-6
- EC Name:
- 1,4-naphthoquinone
- Cas Number:
- 130-15-4
- Molecular formula:
- C10H6O2
- IUPAC Name:
- 1,4-naphthoquinone
1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Duration of exposure:
- 4 h
Results and discussion
Any other information on results incl. tables
The acute inhalation toxicity of 95.8% pure 1,4 -naphthoquinone was studied in accordance with OECD guideline No. 403. Groups of 5 male and 5 female Sprague Dawley rats (initial weight ca. 200 g) were exposed to 1,4 -naphthoquinone as a solid aerosol by inhalation at analytically determined concentrations of 0.065, 0.036 and 0.021 mg/l air for 4 hours (whole body exposure) with an observation period of 14 days The mean aerodvnamic particle diameter was 3.8 to 4.2 µm anel the respirable fraction <6 µm) was between 64.4 and 69.8%. During exposure, signs of irritation of the eyes and respiratory tract, which continued into the observation period, were seen in all concentration groups. Clouding of the cornea developed in 5/17 surviving animals in the intermediat and low concentration groups. Feed and water consumption was decreased for up to 7 and 5 days after exposure, respectively. Body weight declined for up to 5 days after exposure and the weight of the surviving rats did not reach that of the control animals again by the end of the observation period, except in the low concentration group. Post-mortems revealed congestion of the lungs, which were mottled in places, and histological examination showed vacuolisation and necrotic foci in the liver cells. The LC50 values were 0.039 mg/l in males, 0.053 mg/l in females and 0.046 mg/l for both sexes combined.
ormal respiration, reduction in food consumption and body weight, pale and mottled lungs, microscopic changes in lungs
(congestion), livers (hepatocyte vacuolisation, necrosis, congestion/dilatation) and kidneys (tubular basophilia, dilatation of tubular lumen).
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 based on GHS criteria
- Conclusions:
- LC 50=0.046 mg/l
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.