Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 609-330-5 | CAS number: 370865-89-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 3-ethyl-1-methyl-1H-Imidazolium salt with N-cyanocyanamide (1:1)
- EC Number:
- 609-330-5
- Cas Number:
- 370865-89-7
- Molecular formula:
- C6 H11 N2 .C2 N3
- IUPAC Name:
- 3-ethyl-1-methyl-1H-Imidazolium salt with N-cyanocyanamide (1:1)
Constituent 1
- Specific details on test material used for the study:
- - Name of the test substance (as cited in study report): EMIM Dicyanamid
- Purity: 97.4 g/100 g
- Density [g/mL]: 1.099 (determined by Bioassay)
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- - Age/weight: Young adult animals of a comparable weight were used.
- Acclimatization period: at least 5 days before the beginning of the experimental phase; during the acclimatization period, the animals were accustomed to the environmental conditions of the study and to the diet.
- Individual animal identification: by cage cards and tail marking.
- Conditions: the animals were housed in fully air-conditioned rooms. Central air-conditioning guaranteed a range of 22°C ± 3°C for temperature and of 30 – 70% for relative humidity. The day/night rhythm was 12 h light and 12 h darkness.
- Housing: single housing in Makrolon cages, type III.
- Diet: VRF1(P); SDS Special Diets Services, 67122 Altrip, Germany. Feed was withdrawn from the animals at least 16 hours before administration.
- Water: Tap water ad libitum
Administration / exposure
- Route of administration:
- oral: capsule
- Vehicle:
- other: unchanged and water
- Details on oral exposure:
- For the high dose, the liquid test item was administered unchanged. For the lower dose, an administration volume of 2 mL/kg bw of suitable test item preparations was used to facilitate application. The test item preparation was produced for the 500 mg/kg application group shortly before application by stirring with a magnetic stirrer. Concentration used: 25 g/100 mL (500 mg/kg dose level). Form of administration: solution.
- Doses:
- 500 and 2000 mg/kg
- No. of animals per sex per dose:
- - 500 mg/kg: 3
- 2000 mg/kg: 6 - Control animals:
- no
- Details on study design:
- - Observation period: 14 days
- Individual body weight determination shortly before administration (day 0), weekly thereafter and on the last day of observation.
- Recording of clinical signs several times on the day of administration, and at least once daily thereafter each workday for the individual animals.
- A check for any dead or moribund animals was made at least once each workday.
- Necropsy with gross-pathology examination on the last day of the observation period after sacrifice by CO2 inhalation in a chamber with increasing concentrations over time. Necropsy of all animal that died before as early as possible after death.
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- - 2000 mg/kg (first test group): 1/3 animals
- 2000 mg/kg (second test group): no deaths - Clinical signs:
- other: - 2000 mg/kg (first test group): Impaired and poor general state, dyspnoea, piloerection, tremor, staggering, abdominal position, tonic convulsions, exsiccosis, reduced feces, none feces - 2000 mg/kg (second test group): impaired and poor general state, d
- Gross pathology:
- Animal that died: liquid clear content in the stomach, red discoloration of the glandular stomach, dark red discoloration of the liver. There were no macroscopic pathological findings in the surviving animals sacrificed at the end of the observation period.
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.