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Diss Factsheets
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EC number: 700-161-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_environmental-fate-and-pathways.png)
Biodegradation in water and sediment: simulation tests
Some information in this page has been claimed confidential.
Administrative data
- Endpoint:
- biodegradation in water: sediment simulation testing
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Although data provided have a report year after 2008, the data was obtained from a journal article which does not provide GLP information.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 013
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 308 (Aerobic and Anaerobic Transformation in Aquatic Sediment Systems)
- Deviations:
- no
- GLP compliance:
- not specified
Test material
- Details on test material:
- - Purity: > 97%
Constituent 1
- Radiolabelling:
- yes
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- natural water / sediment
- Details on source and properties of surface water:
- The river water was collected from Brandywine Creek, PA at the position of Latitude 39 51 min 34 s, longitude 75 35 min 55 s, and 78 m above sea level.
- Details on source and properties of sediment:
- The river sediment was collected from Brandywine Creek, PA at the position of Latitude 39° 51 min 34 s, longitude 75° 35 min 55 s, and 78 m above sea level. The cobblestones and decayed leaves were discarded from the sediment after bringing the sediment to the laboratory. The sediment physicochemical characteristics were determined. The collected sediment was sandy loam (67% sand, 24% silt, and 9% clay) with 5.3% organic matter or 3.1% organic carbon content. The pH of the sediment was 6.9 and the cation exchange capacity (CEC) was 86 mmol/kg sediment.
- Details on inoculum:
- - Source of inoculum/activated sludge: organisms native to the water and sediment
- Preparation of inoculum for exposure: incubated at room temperature for 5 days before dosing - Duration of test (contact time):
- 100 d
Initial test substance concentration
- Initial conc.:
- 50 other: µg/bottle
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- test mat. analysis
- Details on study design:
- TEST CONDITIONS
- Volume of test solution/treatment: 50 µg/bottle
- Composition of medium: 5 mL mineral media - 85 mg/L of KH2PO4, 218 mg/L of K2HPO4, 334 mg/L of Na2HPO4•2H2O, 5 mg/L of NH4Cl, 36.4 mg/L of CaCl2•2H2O, 22.5 mg/L of MgSO4•7H2O, and 0.25 mg mg/L of FeCl3•6H2O with a pH of 7.0.
- Test temperature: room temperature
TEST SYSTEM
- Culturing apparatus: 119-mL glass serum bottles
- Number of culture flasks/concentration: 3 live, 3 sterile control, and 2 live matrix control bottles for each sampling time
- Method used to create aerobic conditions: two SPE cartridges enabled air exchange between headspace and ambient air and also captured
volatiles during biotransformation.
SAMPLING
- Sampling frequency: days 0, 2, 7, 14, 28, 56, and 100
- Sampling method: extract entire contents including septa and SPE cartridges
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes
- Abiotic sterile control: yes
Results and discussion
Mean total recoveryopen allclose all
- Compartment:
- other: water, material (mass) balance
- % Recovery:
- 16
- Compartment:
- other: sediment, material (mass) balance
- % Recovery:
- 39
% Degradation
- % Degr.:
- >= 93.9 - <= 96.1
- Parameter:
- test mat. analysis
- Sampling time:
- 28 d
- Remarks on result:
- other: Primary degradation
Half-life of parent compound / 50% disappearance time (DT50)
- Compartment:
- entire system
- DT50:
- 1.8 d
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: Mass balance at day 100: 16% in water, 39% in sediment, 15% in headspace
- Transformation products:
- yes
Identity of transformation productsopen allclose all
- Evaporation of parent compound:
- yes
- Volatile metabolites:
- yes
- Residues:
- yes
- Details on results:
- TEST CONDITIONS
- Aerobicity (or anaerobicity), moisture, temperature and other experimental conditions maintained throughout the study: Yes
Any other information on results incl. tables
5:3 Acid is a predominant product during the test substance aerobic biotransformation in river sediment. PFPeA, PFHxA, and PFBA also are formed during the test substance biotransformation in river sediment. 5:3 Acid was sediment-bound and can only be recovered by post-treatment with NaOH and ENVI-Carb™. The 5:3 acid can be further degraded to 4:3 acid in river sediment via one-carbon removal pathways.
Applicant's summary and conclusion
Validity criteria
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test substance biotransformation was rapid (T1/2 < 2 days). By day 28 primary degradation was 93.9 to 96.1%
- Executive summary:
A novel aerobic sediment experimental system containing 20 g wet sediment and 30 mL aqueous solution was developed to study biotransformation in river sediment. The test substance was dosed into the sediment to follow its biotransformation and to analyse transformation products over 100 days.
The test substance biotransformation was rapid, half-life was 1.8 days. By day 28 primary degradation was 93.9 to 96.1%. 5:3 Acid is a predominant product during the test substance aerobic biotransformation in river sediment. PFPeA, PFHxA, and PFBA also were formed during the test in river sediment. 5:3 Acid was sediment-bound and can only be recovered by post-treatment with NaOH and ENVI-Carb™. The 5:3 acid can be further degraded to 4:3 acid in river sediment via one-carbon removal pathways.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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