Registration Dossier
Registration Dossier
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EC number: 601-017-1 | CAS number: 110964-79-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1996-07-03 to 1996-07-26
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well performed OECD and GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- rats received a single oral dose of 5000mg/kg
- Principles of method if other than guideline:
- rats received a single oral dose of 5000mg/kg
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 4-methanesulfonyl-2-nitrobenzoic acid
- EC Number:
- 601-017-1
- Cas Number:
- 110964-79-9
- Molecular formula:
- C8 H7 N1 O6 S1
- IUPAC Name:
- 4-methanesulfonyl-2-nitrobenzoic acid
- Details on test material:
- - Name of test material (as cited in study report): 2-nitro-4-methylsulfonyl benzoic acid
- Physical state: Solid
- Analytical purity: 97%
- Lot/batch No.: WRC 15483-30-1
- Storage condition of test material: Ambient temperature in the dark
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Alpk: APfSD (Wistar-derived)
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Remarks on result:
- other: limit test
- Mortality:
- 0/10
- Clinical signs:
- other: No signs of toxicity
- Gross pathology:
- No treatment related findings were seen at examination post mortem.
- Other findings:
- No other findings
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The acute oral median lethal dose of 2-nitro-4-methylsulfonyl benzoic acid is in excess of 5000mg/kg to male and female rats.
- Executive summary:
A group of five male and five female Alpk: APfSD (Wistar-derived) rats received a single oral dose of 5000 mg/kg of 2-nitro-4-methylsulfonyl benzoic acid. The animals were assessed daily for the following 14 days for any signs of systemic toxicity and their bodyweights were recorded at intervals throughout the study. At the end of the study all the animals were killed and subjected to a macroscopic examination post mortem.
No signs of toxicity were seen and none of the animals died before the scheduled termination. All animals had exceeded their initial bodyweight by the end of the study. No treatment related findings were seen at examination post mortem.
The acute oral median lethal dose of 2-nitro-4-methylsulfonyl benzoic acid is in excess of 5000mg/kg to male and female rats.
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