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EC number: 233-397-6 | CAS number: 10139-58-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13-14 May 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Conducted according to GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 435 (In Vitro Membrane Barrier Test Method for Skin Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Rhodium(III) nitrate hydrate
- EC Number:
- 603-842-2
- Cas Number:
- 13465-43-5
- Molecular formula:
- H4N3O11Rh
- IUPAC Name:
- Rhodium(III) nitrate hydrate
- Reference substance name:
- Rhodium trinitrate hydrate
- IUPAC Name:
- Rhodium trinitrate hydrate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): rhodium trinitrate hydrate - solid
- Physical state: Brown solid
- Analytical purity: Not specified.
- Impurities (identity and concentrations): Not specified.
- Composition of test material, percentage of components: Rhodium content 35.28% w/w
- Isomers composition: Not specified.
- Purity test date: Not specified.
- Lot/batch No.: 10211
- Expiration date of the lot/batch: 31 December 2014
- Stability under test conditions: Not specified.
- Storage condition of test material: Room temperature.
Constituent 1
Constituent 2
Test animals
- Species:
- other: Not applicable.
- Strain:
- other: Not applicable.
- Details on test animals or test system and environmental conditions:
- The CORROSITEX™ Assay is a standardized, quantitative in vitro test for skin corrosivity and has been validated by the ECVAM for testing acids, bases and their derivatives.
The test was performed on a synthetic macromolecular bio-barrier membrane resting on top of a chemical detection system (CDS). The BIOBARRIER was prepared at least 2 hours prior to tests. BIOBARRIER diluent and matrix powder were combined and heated to 68 deg C under smooth agitation. After complete dissolution, the solution was allowed to sit for 5 minutes. 200 µl of the BIOBARRIER were pipetted into each membrane disc, set on the tray and kept in the cold (2-8 deg C) for at least 2 hours.
Test system
- Type of coverage:
- other: Not applicable.
- Preparation of test site:
- other: Not applicable.
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: Negative control: citric acid (10% aq.); positive controls: nitric acid (69%), phosphoric acid (85%)
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- Up to 4 hours.
- Observation period:
- The test system was observed until a reaction was detected (or for a total of 4 hours).
- Number of animals:
- Not applicable.
The test was performed on a total of eight BIOBARRIERS (four BIOBARRIERS for the test item).
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- other: CORROSITEX time (minutes)
- Run / experiment:
- mean of 4 replicates
- Value:
- 18.36
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- positive indication of irritation
Any other information on results incl. tables
Qualification/categorisation test:
The test substance was compatible with the CORROSITEX™ test system. As the sample was intensely coloured, any colour-change reaction in the categorisation tubes was indistinct. Based on pH measurement the test substance was assigned to Category 1.
Positive and negative control test substances:
The reaction times of positive controls nitric acid and phosphoric acid were 1.40 and 16 minutes, respectively. The reaction time of the negative control was 83 minutes. The acceptance criteria for the control substances were therefore fulfilled.
CORROSITEX™ Assay:
The mean time of the test substance to activate the CDS was 18.36 minutes.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
- Conclusions:
- In an in vitro membrane barrier test (CORROSITEX™ Assay) conducted according to OECD guidelines and to GLP, rhodium(III) trinitrate hydrate (solid) displayed a mean breakthrough time of 18.36 minutes. The test substance is classified as "corrosive" sub category 1B, according to UN GHS criteria, as the mean time to activate the CDS was between 3-60 minutes (category 1).
- Executive summary:
In a good quality GLP study, conducted according to OECD test guideline 435, the potential of rhodium(III) trinitrate hydrate (solid) to induce skin corrosion was assessed in the "in vitro membrane barrier test (CORROSITEX™ Assay)".
The test item was placed on top of a BIOBARRIER membrane which was sat on a chemical detection system (CDS) in a vial. Corrosivity is determined on the ability (measured by the time taken) of a chemical to break through the barrier and subsequently activate the underlying CDS (as seen by a colour or consistency change). The mean time required for rhodium(III) trinitrate hydrate (solid) to activate the CDS was 18.36 minutes (mean of 4 replicates).
The test substance is therefore classified as "corrosive" sub category 1B, according to UN GHS criteria, as the mean time to activate the CDS was between 3 -60 minutes (category 1).
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