Registration Dossier
Registration Dossier
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EC number: 204-898-7 | CAS number: 128-60-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion, other
- Remarks:
- in vivo
- Type of information:
- other: read across from similar substance
- Adequacy of study:
- weight of evidence
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- BASF method
- GLP compliance:
- no
Test material
- Reference substance name:
- Violanthrene-5,10-dione
- EC Number:
- 204-152-0
- EC Name:
- Violanthrene-5,10-dione
- Cas Number:
- 116-71-2
- Molecular formula:
- C34H16O2
- IUPAC Name:
- anthra[9,1,2-cde]benzo[rst]pentaphene-5,10-dione
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Himalayan
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- pasted
- Amount / concentration applied:
- 0.5 g
- Duration of treatment / exposure:
- 20 hours
- Observation period:
- 8 days
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: back
REMOVAL OF TEST SUBSTANCE
- Washing (if done): -
- Time after start of exposure: 20 h
OBSERVATION TIME POINTS
24 hours, 8 days
SCORING SYSTEM:
- Parameters evaluated: reddening, edema, scabbing, necrosis, scarification
- Descriptors: questionable, minimal, moderate, marked, without effect
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 8 days
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- other:
- Remarks:
- not irritating
- Conclusions:
- not irritating
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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